Melanopsin-positive intrinsically photosensitive retinal ganglion cells: from form to function.
Melanopsin-positive intrinsically photosensitive retinal ganglion cells: from form to function.
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DOI：
10.1523/jneurosci.4132-11.2011
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发表时间：
2011-11-09
期刊：
影响因子：
--
通讯作者：
Matynia A
中科院分区：
文献类型：
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作者：
Schmidt TM;Do MT;Dacey D;Lucas R;Hattar S;Matynia A
黑视素赋予视网膜神经节细胞（ipRGC）的一个亚类固有光敏性。通常被认为是辐照度检测器，ipRGC靶向参与非图像形成视觉的许多大脑区域。ipRGC将其内在的黑视蛋白介导的光信息与经由突触连接传递的视杆/视锥信号整合以影响光依赖性行为。早期的观察表明这些细胞之间的多样性，最近已经确定了几个特定的亚型。这些亚型在形态和生理形式上不同，控制不同的功能，从生物节律通过昼夜光诱导，到保护性行为反应，包括瞳孔收缩和避光，甚至成像视觉。在这篇微对称综述中，我们将讨论一些最近的发现，这些发现突出了这些最近发现的非典型光感受器的形式和功能的多样性。
Melanopsin imparts an intrinsic photosensitivity to a subclass of retinal ganglion cells (ipRGCs). Generally thought of as irradiance detectors, ipRGCs target numerous brain regions involved in non-image forming vision. ipRGCs integrate their intrinsic, melanopsin-mediated light information with rod/cone signals relayed via synaptic connections to influence light dependent behaviors. Early observations indicated diversity amongst these cells and recently several specific subtypes have been identified. These subtypes differ in morphological and physiological form, controlling separate functions that range from biological rhythm via circadian photoentrainment, to protective behavioral responses including pupil constriction and light avoidance, and even image-forming vision. In this minisymposium review, we will discuss some recent findings that highlight the diversity in both form and function of these recently discovered atypical photoreceptors.