Current status of the management of symptomatic intracranial atherosclerotic disease: the rationale for a randomized trial of medical therapy and intracranial stenting
Current status of the management of symptomatic intracranial atherosclerotic disease: the rationale for a randomized trial of medical therapy and intracranial stenting
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DOI：
10.1136/jnis.2009.000125
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发表时间：
2009-07-01
影响因子：
4.8
通讯作者：
Chimowitz, M. I.
中科院分区：
文献类型：
--
作者：
Fiorella, D.;Turan, T. N.;Chimowitz, M. I.
支架植入术和积极的医疗管理预防颅内狭窄患者复发性卒中（SAMMPRIS）是一项随机试验，比较了在症状性、高度颅内狭窄患者中单独使用积极的医疗管理与积极的医疗管理联合使用Gateway-Wingspan系统的血管成形术和支架植入术。这项试验代表了神经干预领域成熟的一个里程碑，为循证实践奠定了基础。我们回顾了症状性颅内狭窄的自然史，可用的介入治疗和SAMMPRIS试验设计的基本原理。
Stenting and Aggressive Medical Management for Preventing Recurrent stroke in Intracranial Stenosis (SAMMPRIS) is a randomized trial comparing aggressive medical management alone with aggressive medical management in combination with angioplasty and stenting using the Gateway-Wingspan system in patients with symptomatic, high-grade, intracranial stenosis. This trial represents a landmark in the maturation of the field of neurointervention, establishing a foundation for evidenced-based practice. We review the natural history of symptomatic intracranial stenosis when treated medically, the available interventional therapies and the rationale for the design of the SAMMPRIS trial.