Effects of PTH on osteocyte function.
Effects of PTH on osteocyte function.
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DOI：
10.1016/j.bone.2012.09.016
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发表时间：
2013-06
期刊：
影响因子：
4.1
通讯作者：
Pajevic PD
中科院分区：
文献类型：
--
作者：
Bellido T;Saini V;Pajevic PD
骨细胞的理想位置是检测和响应机械和激素刺激，并协调成骨细胞和破骨细胞的功能。然而，支持骨细胞参与骨骼生物学特定方面的证据有限，主要是由于缺乏合适的实验方法。在过去的几年里，该领域的一些重要进展显着增加了我们对骨细胞功能的理解。骨细胞系的发展引发了大量的体外研究，这些研究为骨细胞的独特生物学提供了见解，并继续产生新的假设。使用启动子片段指导基因表达到骨细胞的遗传方法允许产生具有特定基因功能的获得或丧失的小鼠，揭示其在骨细胞功能中的作用。此外，Sost/sclerostin主要在骨细胞中表达并抑制成骨细胞的骨形成的证据，推动了试图鉴定该基因的调节因子以及影响成骨细胞和破骨细胞功能的其他骨细胞产物的研究。发现甲状旁腺激素（PTH），骨稳态的中央调节器，抑制sclerostin表达产生了一系列研究，揭示了骨细胞是PTH作用的关键靶细胞。本文综述了这些研究，并讨论了它们的意义，促进我们的理解骨细胞调节骨稳态的机制，并为开发针对骨细胞的骨疾病的治疗。本文是题为“骨细胞”的特刊的一部分。
Osteocytes are ideally positioned to detect and respond to mechanical and hormonal stimuli and to coordinate the function of osteoblasts and osteoclasts. However, evidence supporting the involvement of osteocytes in specific aspects of skeletal biology has been limited mainly due to the lack of suitable experimental approaches. Few crucial advances in the field in the past several years have markedly increased our understanding of the function of osteocytes. The development of osteocytic cell lines initiated a plethora of in vitro studies that have provided insights into the unique biology of osteocytes and continue to generate novel hypotheses. Genetic approaches using promoter fragments that direct gene expression to osteocytes allowed the generation of mice with gain or loss of function of particular genes revealing their role in osteocyte function. Furthermore, evidence that Sost/sclerostin is expressed primarily in osteocytes and inhibits bone formation by osteoblasts, fueled research attempting to identify regulators of this gene as well as other osteocyte products that impact the function of osteoblasts and osteoclasts. The discovery that parathyroid hormone (PTH), a central regulator of bone homeostasis, inhibits sclerostin expression generated a cascade of studies that revealed that osteocytes are crucial target cells of the actions of PTH. This review highlights these investigations and discusses their significance for advancing our understanding of the mechanisms by which osteocytes regulate bone homeostasis and for developing therapies for bone diseases targeting osteocytes. This article is part of a Special Issue entitled "The Osteocyte".
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影响因子：
6.2
作者：
Kim, Sang Wan;Pajevic, Paola Divieti;Selig, Martin;Barry, Kevin J.;Yang, Jae-Yeon;Shin, Chan Soo;Baek, Wook-Young;Kim, Jung-Eun;Kronenberg, Henry M.
通讯作者：
Kronenberg, Henry M.
影响因子：
20.3
作者：
Calvi, Laura M.;Bromberg, Olga;Bellido, Teresita
通讯作者：
Bellido, Teresita
DOI：
10.1152/ajpendo.00502.2004
发表时间：
2005-06-01
影响因子：
5.1
作者：
Ito, M;Sakai, Y;Miyamoto, K
通讯作者：
Miyamoto, K
影响因子：
3.7
作者：
Choi HY;Dieckmann M;Herz J;Niemeier A
通讯作者：
Niemeier A
影响因子：
5.8
作者：
Brown, Whitney W.;Jueppner, Harald;McCormick, Kenneth L.
通讯作者：
McCormick, Kenneth L.