Non-Hodgkin's lymphoma associated membranoproliferative glomerulonephritis: rare case of long term remission with chemotherapy: a case report.
Non-Hodgkin's lymphoma associated membranoproliferative glomerulonephritis: rare case of long term remission with chemotherapy: a case report.
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DOI：
10.1186/1757-1626-0002-0000007201
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发表时间：
2009-09-15
期刊：
影响因子：
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通讯作者：
Wall BM
中科院分区：
文献类型：
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作者：
Alshayeb H;Wall BM
虽然膜增生性肾小球肾炎已被报道与非霍奇金淋巴瘤相关，但关于非霍奇金淋巴瘤治疗对相关膜增生性肾小球肾炎的长期影响的信息有限。本报告描述了一个病人谁提出了突然发作的高血压，混合性肾病/肾病综合征和急性肾功能衰竭。肾活检结果与1型膜增生性肾小球肾炎一致。在评估主动脉周围淋巴结病、肝脾肿大和血小板减少症时进行的骨髓活检证实了低级别B细胞非霍奇金淋巴瘤的诊断。患者的肾功能改善，蛋白尿解决后，初步治疗非霍奇金淋巴瘤化疗。在11年的随访中，膜增生性肾小球肾炎一直处于缓解状态，如反复阴性尿分析、正常血压和无提示肾炎/肾病综合征的临床体征和症状所证实。已知膜增生性肾小球肾炎与慢性淋巴细胞白血病和非霍奇金淋巴瘤，特别是与B细胞淋巴细胞型非霍奇金淋巴瘤相关。关于非霍奇金淋巴瘤治疗对非霍奇金淋巴瘤相关膜增生性肾小球肾炎进展的影响，现有信息有限。在少数报告的情况下，我们发现，缺乏长期随访后，初步解决的膜增生性肾小球肾炎。本报告提出一个罕见的非何杰金氏淋巴瘤相关膜增生性肾小球肾炎的病例，在淋巴瘤的初始化疗治疗后的11年随访期间持续缓解。
Although membranoproliferative glomerulonephritis has been reported to occur in association with non-Hodgkin's lymphoma, information concerning the long term effects of treatment of non-Hodgkin's lymphoma on the associated membranoproliferative glomerulonephritis is limited. The current report describes a patient who presented with the abrupt onset of hypertension, mixed nephritic/nephrotic syndrome and acute renal failure. Kidney biopsy was consistent with membranoproliferative glomerulonephritis, type 1. Bone marrow biopsy performed in the evaluation of periaortic lymphadenopathy, hepatosplenomegaly, and thrombocytopenia confirmed the diagnosis of low grade B-cell non-Hodgkin's lymphoma. The patient's renal function improved and proteinuria resolved after initial treatment of non-Hodgkin's lymphoma with chemotherapy. During eleven years of follow up, membranoproliferative glomerulonephritis has remained in remission, as confirmed by repeatedly negative urinalyses, normal blood pressure and absence of clinical signs and symptoms suggestive of nephritic/nephrotic syndrome. Membranoproliferative glomerulonephritis has been known to be associated with both chronic lymphocytic leukemia and non-Hodgkin's lymphoma, particularly with B cell lymphocytic type non-Hodgkin's lymphoma. There is limited information available concerning the effects of treatment of non-Hodgkin's lymphoma on the progression of non-Hodgkin's lymphoma associated membranoproliferative glomerulonephritis. In the few reported cases we found, long term follow up after initial resolution of the membranoproliferative glomerulonephritis was lacking. This report presented a rare case of non-Hodgkin's lymphoma associated membranoproliferative glomerulonephritis, that continued to be in remission during eleven years of follow up after initial chemotherapy treatment of lymphoma.