Patients with premenstrual dysphoric disorder have increased startle modulation during anticipation in the late luteal phase period in comparison to control subjects
Patients with premenstrual dysphoric disorder have increased startle modulation during anticipation in the late luteal phase period in comparison to control subjects
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DOI：
10.1016/j.psyneuen.2011.02.011
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发表时间：
2011-09-01
影响因子：
3.7
通讯作者：
Poromaa, Inger Sundstrom
中科院分区：
文献类型：
--
作者：
Bannbers, Elin;Kask, Kristiina;Poromaa, Inger Sundstrom
听觉惊吓反应（acoustic startle response，ASR）是对突然或有害听觉刺激的退缩反射，最重要的是，它是对食欲和厌恶刺激的情绪处理的无偏测量。通过将受试者暴露在恐惧的情况下，如令人厌恶的图片，ASR可能会增强，这表明杏仁核在威胁情况下调节惊吓回路。作为一个以前的研究，调查情感调制的ASR的妇女与经前焦虑症（PMDD），发现没有差异，在图片观看它可能是情绪变化观察到的PMDD与焦虑的预期，而不是直接刺激反应。因此，我们试图检查PMDD对图片预期和图片反应的影响。16名PMDD患者和16名对照者在月经周期的卵泡期和黄体期观看了包含令人愉快和不愉快的图片以及积极和消极预期刺激的幻灯片。与对照组相比，PMDD患者在月经周期的黄体期对正性和负性预期刺激的惊吓调制增强。这一发现主要是由PMDD患者中黄体期与卵泡期相比调节增加所致，但也由患者黄体期与对照组相比调节增加所致。这表明，在此期间，神经回路的情绪预期反应更敏感，并强调需要检查的神经相关的PMDD妇女的预期过程。(C)2011爱思唯尔有限公司版权所有。
The acoustic startle response (ASR) is a withdrawal reflex to sudden or noxious auditory stimuli and, most importantly, an unbiased measure of emotional processing of appetitive and aversive stimuli. By exposing subjects to fearful situations, such as aversive pictures, the ASR may be enhanced, suggesting that amygdala modulates the startle circuit during threat situations. As one previous study, investigating affective modulation of the ASR in women with premenstrual dysphoric disorder (PMDD), discovered no difference during picture viewing it is possible that the mood changes observed in PMDD relate to anxious anticipation rather than to direct stimulus responding. Hence we sought to examine the effects of PMDD on picture anticipation and picture response.Sixteen PMDD patients and 16 controls watched slide shows containing pleasant and unpleasant pictures and positive and negative anticipation stimuli during the follicular and luteal phase of the menstrual cycle. Simultaneously, semi-randomized startle probes (105 dB) were delivered and the ASR was assessed with electromyography.Compared with control subjects, PMDD patients displayed an enhanced startle modulation by positive and negative anticipation stimuli in the luteal phase of the menstrual cycle. This finding was mainly driven by increased modulation in the luteal phase in comparison to the follicular phase among PMDD patients but also by an increased modulation in patients compared to controls during luteal phase. This suggests that the neural circuits underlying response to emotional anticipation are more sensitive during this period and emphasize the need of examining the neural correlates of anticipatory processes in women with PMDD. (C) 2011 Elsevier Ltd. All rights reserved.