Case-control association study of the close homologue of L1 (CHL1) gene and schizophrenia in the Chinese population
Case-control association study of the close homologue of L1 (CHL1) gene and schizophrenia in the Chinese population
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DOI：
10.1016/j.schres.2004.06.001
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发表时间：
2005-03-01
影响因子：
4.5
通讯作者：
He, L
中科院分区：
文献类型：
--
作者：
Chen, QY;Chen, Q;He, L
位于人类染色体3p26.1上的L1同源分子（CHL1）是新发现的细胞粘附分子L1家族的成员，在细胞迁移、轴突生长和突触重塑中起重要作用。据报道，日本人群中CHL1基因错义多态性与精神分裂症之间存在正相关[Sakurai， K., Migita， O., Toru， M., Arinami, T ., 2002]。L1近同源基因（CHL1， CALL）错义多态性与精神分裂症的关系。《精神病学杂志》[j]。L1近同源基因（CHL1， CALL）错义多态性与精神分裂症的关系。为了验证这一发现，我们使用560例汉族人群和576例对照样本对该基因中的4个snp进行了基因分型。两份样本的等位基因频率分析也显示SNP rs2272522 （K. Sakurai研究的同一标记）与疾病之间有很强的关联(X-2 =31.591， P
The close homolog of L1 (CHL1), located on human chromosome 3p26.1, is a newly identified member of the L1 family of cell adhesion molecules which play important roles in cell migration, axonal growth, and synaptic remodeling. A positive association has been reported between a missense polymorphism in CHL1 gene and schizophrenia in the Japanese population [Sakurai, K., Migita, O., Toru, M., Arinami, T, 2002. An association between a missense polymorphism in the close homologue of L1 (CHL1, CALL) gene and schizophrenia. Mol. Psychiatry 7, 412-415]. An association between a missense polymorphism in the close homologue of L1 (CHL1, CALL) gene and schizophrenia. In order to test this finding, we genotyped four SNPs in the gene in the Han Chinese population using a sample of 560 cases and 576 controls. Analysis of allele frequencies in both samples also showed strong association between SNP rs2272522 (the same marker studied by K. Sakurai) and the disease (X-2 =31.591, P