Impact of heart disease and calibration interval on accuracy of pulse transit time-based blood pressure estimation
Impact of heart disease and calibration interval on accuracy of pulse transit time-based blood pressure estimation
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DOI：
10.1088/0967-3334/37/2/227
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发表时间：
2016-02-01
影响因子：
3.2
通讯作者：
Tsang, Hon Ki
中科院分区：
文献类型：
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作者：
Ding, Xiaorong;Zhang, Yuanting;Tsang, Hon Ki
无袖带连续测量血压有利于高血压的早期发现和预防。脉冲通过时间(PTT)法已被证明是一种有希望的连续无袖带血压测量方法。然而，准确性问题是该方法大规模临床应用前最具挑战性的方面之一。由于基于PTT的BP估计在某些假设下主要依赖于PTT和BP之间的关系，因此估计的准确性将受到损害这种关系的心血管疾病和可能违反这些假设的校准频率的影响。这项研究试图检查心脏病和校准间隔对基于PTT的BP估计的准确性的影响。对37名健康受试者和48名心脏病患者在不同的校准时间间隔，即初始校准后15分钟、2周和1个月，对PTT-BP算法的准确性进行了研究。结果表明，心脏病患者的收缩压估计总体准确度明显低于健康人，但舒张压估计的准确性高于健康人。随着校准间隔的延长，收缩压和舒张压估计的准确性变得不那么可靠。这些结果表明，心脏病和校准间隔都会影响基于PTT的BP估计的准确性，应该考虑到这一点以提高估计精度。
Continuous blood pressure (BP) measurement without a cuff is advantageous for the early detection and prevention of hypertension. The pulse transit time (PTT) method has proven to be promising for continuous cuffless BP measurement. However, the problem of accuracy is one of the most challenging aspects before the large-scale clinical application of this method. Since PTT-based BP estimation relies primarily on the relationship between PTT and BP under certain assumptions, estimation accuracy will be affected by cardiovascular disorders that impair this relationship and by the calibration frequency, which may violate these assumptions. This study sought to examine the impact of heart disease and the calibration interval on the accuracy of PTT-based BP estimation. The accuracy of a PTT-BP algorithm was investigated in 37 healthy subjects and 48 patients with heart disease at different calibration intervals, namely 15 min, 2 weeks, and 1 month after initial calibration. The results showed that the overall accuracy of systolic BP estimation was significantly lower in subjects with heart disease than in healthy subjects, but diastolic BP estimation was more accurate in patients than in healthy subjects. The accuracy of systolic and diastolic BP estimation becomes less reliable with longer calibration intervals. These findings demonstrate that both heart disease and the calibration interval can influence the accuracy of PTT-based BP estimation and should be taken into consideration to improve estimation accuracy.