Sun exposure and malignant lymphoma: A population-based case-control study in Germany
Sun exposure and malignant lymphoma: A population-based case-control study in Germany
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DOI：
10.1002/ijc.22492
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发表时间：
2007-06-01
影响因子：
6.4
通讯作者：
Seidler, Andreas
中科院分区：
文献类型：
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作者：
Weihkopf, Thomas;Becker, Nikolaus;Seidler, Andreas
虽然恶性淋巴瘤的一些原因是已知的，但其病因至今仍不清楚。我们在一项多中心、以人群为基础的病例对照研究中分析了阳光照射与恶性淋巴瘤之间的关系。在德国的6个研究地区前瞻性招募恶性淋巴瘤患者（n = 710，18-80岁）。对于每种情况，性别，地区和年龄匹配的控制来自人口登记。在个人访谈中，记录了在阳光明媚的气候中度过的终身假期，户外休闲活动和日光浴床或日光灯的使用。职业医师以工作任务特定补充问卷为基础，评估累积外出工作时间。采用条件Logistic回归分析计算比值比（OR）和95%置信区间（CI），并对吸烟和饮酒进行校正。为了增加统计功效，使用非条件logistic回归将具有特定淋巴瘤子实体的患者与整个对照组进行额外比较。我们观察到在阳光充足的气候下度假或经常使用日光浴床或日光灯的受试者总体淋巴瘤风险降低。淋巴瘤亚型的分析显示了类似的结果，除了T-NHL和滤泡性淋巴瘤与户外休闲活动呈正相关。虽然累计工作时间外似乎无关NHL的整体和大多数子实体，它是负相关的滤泡性淋巴瘤和HL弱阳性。这些数据表明，暴露于自然和人工紫外线辐射可能会降低本研究人群中淋巴瘤的OR。(c)2007 Wiley-Liss，Inc.
Although some causes for malignant lymphoma are known their etiology is not well understood so far. We analyze the relationship between sun exposure and malignant lymphoma in a multicenter, population-based case-control study. Patients with malignant lymphoma (n = 710, 18-80 years) were prospectively recruited in 6 study regions in Germany. For each case, a gender, region and age-matched control was drawn from population-registers. In personal interviews, lifetime holidays spent in sunny climate, outdoor leisure activities and sunbed or sunlamp use were recorded. On basis of job task-specific supplementary questionnaires, an occupational physician assessed the cumulative working time outside. Odds ratios (OR) and 95%-confidence-intervals (CI) were calculated using conditional logistic regression analysis, adjusted for smoking and alcohol consumption. To increase statistical power, patients with specific lymphoma subentities were additionally compared with the entire control group using unconditional logistic regression. We observed a reduced overall lymphoma risk among subjects having spent vacations at sunny climates or frequently used sunbeds or sunlamps. The analysis of lymphoma subentities revealed similar results with the exception of T-NHL and follicular lymphoma which were positively associated with outdoor leisure activities. While cumulative working time outside appeared unrelated to NHL overall and most subentities, it was negatively associated with follicular lymphoma and weakly positively to HL. This data suggest that exposure to natural and artificial ultraviolet radiation may reduce the OR for lymphoma in this study population. (c) 2007 Wiley-Liss, Inc.