Peripheral B cells from patients with hepatitis C virus-associated lymphoma exhibit clonal expansion and an anergic-like transcriptional profile.
Peripheral B cells from patients with hepatitis C virus-associated lymphoma exhibit clonal expansion and an anergic-like transcriptional profile.
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DOI：
10.1016/j.isci.2022.105801
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发表时间：
2023-01-20
期刊：
影响因子：
5.8
通讯作者：
De Giorgi, Valeria
中科院分区：
文献类型：
--
作者：
Henning, Amanda N.;Budeebazar, Myagmarjav;Boldbaatar, Delgerbat;Yagaanbuyant, Dahgwahdorj;Duger, Davaadorj;Batsukh, Khishigjargal;Zhou, Huizhi;Baumann, Ryan;Allison, Robert D.;Alter, Harvey J.;Dashdorj, Naranjargal;De Giorgi, Valeria
Chronic HCV infection remains a global health concern due to its involvement in hepatic and extrahepatic diseases, including B cell non-Hodgkin lymphoma (BNHL). Clinical and epidemiological evidence support a causal role for HCV in BNHL development, although mechanistic insight is lacking. We performed RNA-sequencing on peripheral B cells from patients with HCV alone, BNHL alone, and HCV-associated BNHL to identify unique and shared transcriptional profiles associated with transformation. In patients with HCV-associated BNHL, we observed the enrichment of an anergic-like gene signature and evidence of clonal expansion that was correlated with the expression of epigenetic regulatory genes. Our data support a role for viral-mediated clonal expansion of anergic-like B cells in HCV-associated BNHL development and suggest epigenetic dysregulation as a potential mechanism driving expansion. We propose epigenetic mechanisms may be involved in both HCV-associated lymphoma and regulation of B cell anergy, representing an attractive target for clinical interventions. Anergic-like gene signature seen in peripheral B cells from patients with BNHL/HCV Also observed expansion of lymphoproliferative and autoimmune-associated clonotypes Clonotype expansion correlated with epigenetic upregulation Epigenetic dysregulation may be involved in lymphoprogression and B cell anergy Epigenetics; Immunology; Virology
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影响因子：
46.9
作者：
Bolotin DA;Poslavsky S;Davydov AN;Frenkel FE;Fanchi L;Zolotareva OI;Hemmers S;Putintseva EV;Obraztsova AS;Shugay M;Ataullakhanov RI;Rudensky AY;Schumacher TN;Chudakov DM
通讯作者：
Chudakov DM
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12.8
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Garcia-Alvarez, Maria;Alonso-Alvarez, Sara;Alcoceba, Miguel
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Alcoceba, Miguel
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20.3
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Chan, CH;Hadlock, KG;Levy, S
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Levy, S
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3.7
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Berghaus N;Schreiner S;Granzow M;Müller-Tidow C;Hegenbart U;Schönland SO;Huhn S
通讯作者：
Huhn S
影响因子：
12.8
作者：
Freedman, Arnold;Jacobsen, Eric
通讯作者：
Jacobsen, Eric