Human African trypanosomiasis of the CNS: current issues and challenges
Human African trypanosomiasis of the CNS: current issues and challenges
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DOI：
10.1172/jci200421052
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发表时间：
2004-02-01
影响因子：
15.9
通讯作者：
Kennedy, PGE
中科院分区：
文献类型：
--
作者：
Kennedy, PGE
人类非洲锥虫病（HAT），也称为昏睡病，是撒哈拉以南非洲死亡和发病的主要原因。目前使用美拉胂醇治疗CNS HAT具有不可接受的副作用，总死亡率为5%。本文综述了中枢神经系统疾病的诊断和分期，其神经发病机制，以及治疗晚期疾病的新疗法的可能性。
Human African trypanosomiasis (HAT), also known as sleeping sickness, is a major cause of mortality and morbidity in sub-Saharan Africa. Current therapy with melarsoprol for CNS HAT has unacceptable side-effects with an overall mortality of 5%. This review discusses the issues of diagnosis and staging of CNS disease, its neuropathogenesis, and the possibility of new therapies for treating late-stage disease.