CT of Renal Densities Caused by Intravenous Infusion of Antibiotics
CT of Renal Densities Caused by Intravenous Infusion of Antibiotics
复制标题
静脉输注抗生素引起的肾脏密度CT
DOI：
10.1097/00004728-199503000-00012
复制
发表时间：
1995
影响因子：
1.3
通讯作者：
A. Golik
中科院分区：
文献类型：
--
作者：
R. Starinsky;J. Barr;Gilli Lushkov;M. Segal;Anna Manor;A. Golik
目的观察静脉注射抗生素患者腹部CT表现为肾收集系统衰减增加。为了检测这是否与某些抗生素有关，我们对接受脓毒症治疗同时静脉注射抗生素的患者进行了前瞻性研究。此外，我们还测试了给兔子使用的抗生素。材料与方法对14例患者进行头孢唑林、庆大霉素、头孢噻肟、万古霉素、阿莫西林、克拉维酸（强化）和甲硝唑的检测。10组家兔静脉注射这些药物。在静脉注射抗生素前和后2小时对肾脏进行计算机断层扫描。14例行腹部CT扫描并静脉注射抗生素的患者不注射造影剂。结果头孢唑林、头孢噻肟和庆大霉素是诱导收集系统衰减最有效的抗生素。当药物联合使用时，这种效果是协同的。结论阐明抗生素对正常肾脏收集系统衰减的潜在增加，有助于消除与其他病理如海绵髓样肾的混淆。索引术语抗生素-肾脏-计算机断层扫描。
Objective Patients treated with intravenous antibiotics were seen to have increased attenuation of the renal collecting system on CT scan of the abdomen. To detect whether this was related to certain antibiotics, we undertook a prospective study on patients being treated for sepsis while receiving intravenous antibiotics. In addition, we also tested antibiotics administered to rabbits. Materials and Methods Fourteen patients were tested with cefazolin, gentamicin, cefotaxime, vancomycin, amoxicillin and clavulanic acid (Augmenting and metronidazole. Ten groups of rabbits received these drugs by intravenous injection. Computed tomography scan of the kidneys was performed prior to and 2 h after intravenous injection of antibiotics. Fourteen patients who underwent CT scan of the abdomen and were treated by intravenous antibiotics were scanned without contrast agent injection. Results According to our results, cefazolin, cefotaxime, and gentamicin seemed to be the most potent antibiotics in inducing increased attenuation of the collecting system. This effect was synergistic when a combination of drugs was used. Conclusion The elucidation of the potential increase in attenuation of the collecting system by antibiotics in normally functioning kidneys should help to eliminate confusion with other pathologies such as medullary sponge kidney. Index Terms Antibiotics—Kidneys—Computed tomography.