Sex differences in lipid, lipoprotein, cardiovascular, and neuroendocrine responses to acute stress.
Sex differences in lipid, lipoprotein, cardiovascular, and neuroendocrine responses to acute stress.
复制标题
脂质、脂蛋白、心血管和神经内分泌对急性应激反应的性别差异。
DOI：
10.1111/j.1469-8986.1988.tb01902.x
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发表时间：
1988
期刊：
影响因子：
3.7
通讯作者：
Johnson,CA
中科院分区：
文献类型：
--
作者：
Stoney,CM;Matthews,KA;McDonald,RH;Johnson,CA
本研究有两个目的：（a）检查年轻人在急性行为应激时脂质和脂蛋白是否发生变化;（B）测试应激时脂质、脂蛋白、神经内分泌和心血管变化的性别差异程度。19名女性和22名男性参与了一项连续减法任务、一项录像讲话任务和一项自我评价任务。在休息时和每次应激期间检查低密度和高密度脂蛋白、甘油三酯、游离脂肪酸、肾上腺素、去甲肾上腺素、心率和血压的胆固醇部分。重复测量方差分析表明，与基线相比，低密度和高密度脂蛋白胆固醇、甘油三酯、游离脂肪酸、去甲肾上腺素、心率和血压的应激相关水平升高，并且这些反应部分依赖于任务或顺序。随后的性别差异分析显示，男性在所有任务中的低密度脂蛋白胆固醇和血压升高幅度均大于女性，女性对语音任务的心率反应大于男性。血浆儿茶酚胺调整无性别差异。这些数据表明，高密度和低密度脂蛋白的胆固醇部分增加在急性心理压力，是第一个系统地研究男性/女性的差异，在这些压力反应。
This study had two objectives: (a) to examine whether or not lipids and lipoproteins change in response to acute behavioral stress in young adults; and (b) to test the extent of sex differences in the magnitude of the lipid, lipoprotein, neuroendocrine, and cardiovascular changes during stress. Nineteen women and 22 men participated in a serial subtraction task, a videotaped speech task, and a self‐evaluation task. The cholesterol portions of low density and high density lipoproteins, triglycerides, free fatty acids, epinephrine, norepinephrine, heart rate, and blood pressure were examined at rest and during each stressor. Repeated measures analyses of variance indicated that stress‐related levels of low density and high density lipoprotein‐cholesterol, triglycerides, free fatty acids, norepinephrine, heart rate, and blood pressure were elevated, relative to baseline, and that these responses were partially task or order dependent. Subsequent analyses of sex differences showed that males had larger low density lipoprotein‐cholesterol and blood pressure increases during all tasks, relative to those of females, and females had larger heart rate responses to the speech task, relative to those of males. There were no sex differences in plasma catecholamine adjustments. These data demonstrate that the cholesterol fractions of high and low density lipoproteins increase during acute psychological stress, and are the first to systematically examine male/female differences in those stress responses.