EFFECTS OF THE HYPNOTIC DRUG ETOMIDATE IN A MODEL NERVOUS-SYSTEM (BUCCAL GANGLIA, HELIX-POMATIA)
EFFECTS OF THE HYPNOTIC DRUG ETOMIDATE IN A MODEL NERVOUS-SYSTEM (BUCCAL GANGLIA, HELIX-POMATIA)
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DOI：
10.1016/0742-8413(91)90290-a
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发表时间：
1991-01-01
期刊：
影响因子：
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通讯作者：
SPECKMANN, EJ
中科院分区：
文献类型：
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作者：
ALTRUP, U;LEHMENKUHLER, A;SPECKMANN, EJ
1.用细胞内记录的方法研究催眠药依托咪酯对大鼠颊神经节B1~B4神经元的影响。依托咪酯的阈值剂量为10mU/L时，主要影响神经元间网络。在浓度高于200mU·m-1/L时，该药可诱发典型的癫痫活动(阵发性除极移)。神经元B1至B4在不同浓度范围内产生癫痫活动。PDS通过电触点同步。PDS可被钙拮抗剂维拉帕米阻断，但不能被化学突触传递阻断。与致痫药物戊四氮相比，依托咪酯诱导PDS的有效剂量约低100倍。
1. Effects of the hypnotic drug etomidate were studied with intracellular recordings of the identified neurons B1 to B4 of the buccal ganglia of Helix pomatia.2. At threshold doses of 10-mu-mol/l, etomidate mainly affected interneuronal networks.3. In concentrations above 200-mu-mol/l, the drug induced typical epileptic activities (paroxysmal depolarization shifts, PDS). Neurons B1 to B4 generated epileptic activities in differential concentration ranges. PDS were synchronized via electrical contacts. PDS could be blocked by the "calcium antagonist" verapamil but not by a block of chemical synaptic transmission.4. In comparison with the epileptogenic drug pentylenetetrazol, effective doses of etomidate to induce PDS were about 100 times lower.