Bidirectional encoding of motion contrast in the mouse superior colliculus.
Bidirectional encoding of motion contrast in the mouse superior colliculus.
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作者：
Barchini J;Shi X;Chen H;Cang J
视觉场景中显著物体的检测是动物与环境相互作用的重要方面。在这里，我们表明，在小鼠上级丘（SC）的神经元编码视觉显着性检测刺激中心和周围的运动对比。SC最表层的兴奋性神经元受到情境调制，单调地增加它们的反应，从同向环境的抑制到反向移动环境的最大增强。这种增强作用的程度随着SC深度的增加而下降。抑制性神经元在所有深度都受到任何周围环境的抑制。这两个神经元群体的反应调制更突出的方向对比度比相位，时间频率，或静态方向对比度，这表明功能特定的显着性编码在小鼠SC。总之，我们的研究结果提供了证据支持本地生成的功能表示在SC，并奠定了基础，对他们的出现机制和进化的理解。
Detection of salient objects in the visual scene is a vital aspect of an animal’s interactions with its environment. Here, we show that neurons in the mouse superior colliculus (SC) encode visual saliency by detecting motion contrast between stimulus center and surround. Excitatory neurons in the most superficial lamina of the SC are contextually modulated, monotonically increasing their response from suppression by the same-direction surround to maximal potentiation by an oppositely-moving surround. The degree of this potentiation declines with depth in the SC. Inhibitory neurons are suppressed by any surround at all depths. These response modulations in both neuronal populations are much more prominent to direction contrast than to phase, temporal frequency, or static orientation contrast, suggesting feature-specific saliency encoding in the mouse SC. Together, our findings provide evidence supporting locally generated feature representations in the SC, and lay the foundations towards a mechanistic and evolutionary understanding of their emergence.