Polymorphism G861C of 5-HT receptor subtype 1B is associated with heroin dependence in Han Chinese
Polymorphism G861C of 5-HT receptor subtype 1B is associated with heroin dependence in Han Chinese
复制标题
5-HT受体亚型1B多态性G861C与汉族海洛因依赖相关
DOI：
10.1016/j.bbrc.2011.07.114
复制
发表时间：
2011-09-02
影响因子：
3.1
通讯作者：
Lai, J. H.
中科院分区：
文献类型：
--
作者：
Gao, F.;Zhu, Y. S.;Lai, J. H.
肾上腺素能（5-HT）系统调节广泛脑区域中的神经元活动，并且似乎对于调节行为和生理功能如情绪、情感、睡眠和食欲特别重要。中枢5-HT失调可能参与许多神经心理障碍，包括物质滥用和成瘾。已有研究表明，某些5-HT受体基因的多态性可能与海洛因依赖有关。在此，我们在一个中国汉族人群队列中研究了海洛因依赖与5-HT受体的4个单核苷酸多态性（SNP）（HTR的A-1438 G和T102 C（2A），HTR的G861 C和A1180 G（1B））之间的潜在关联。研究对象包括303名在西安市精神卫生中心接受美沙酮维持治疗的海洛因依赖者和300名健康对照者。所得数据显示，与对照组相比，海洛因依赖受试者中G861 C的HTR（1B）G等位基因的频率显着更高（Bonferroni校正后p = 0.001）。进一步研究G861 C基因型与临床表型的相关性，发现GG基因型患者的海洛因自我注射量明显高于CC和CG基因型患者（p < 0.01）。这些结果提示HTR（1B）基因多态性在中国汉族人群海洛因依赖中的作用，并可能为今后海洛因依赖的遗传学或神经生物学研究提供信息。(C)2011 Elsevier Inc. All rights reserved.
The serotoninergic (5-HT) system regulates neuronal activity in broad brain regions, and appears to be particularly important for modulating behavioral and physiological functions such as mood, emotion, sleep and appetite. Central 5-HT deregulation may be involved in many neuropsychological disorders, which include substance abuse and addiction. Previous studies suggest that genetic polymorphisms in some 5-HT receptor genes may relate to heroin dependency. Here we examined potential association between heroin dependence and four single nucleotide polymorphisms (SNPs) of 5-HT receptors (A-1438G and T102C of HTR(2A), and G861C and A1180G of HTR(1B)) in a cohort of Han Chinese. Participants included 303 heroin-dependent subjects who were recruited into the Methadone Maintenance Treatment (MMT) Program in the Xi'an Mental Health Center, and 300 healthy controls. The resulting data yielded a significantly higher frequency of the HTR(1B) G allele with G861C among the heroin-dependent subjects relative to controls (p = 0.001 after Bonferroni correction). Further genotype and clinical phenotype correlation study of the G861C carriers showed that the amount of heroin self-injection was higher in patients with the GG genotype relative to CC and CG genotypes (p < 0.01). These findings point to a role for HTR(1B) polymorphism in heroin dependence among Han Chinese, and may be informative for future genetic or neurobiological studies on heroin dependence. (C) 2011 Elsevier Inc. All rights reserved.