Immunohistochemical expression of platelet growth factor and vascular endothelial growth factor in patients with melanoma with and without redness (Brenner sign)
Immunohistochemical expression of platelet growth factor and vascular endothelial growth factor in patients with melanoma with and without redness (Brenner sign)
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DOI：
10.1001/archderm.143.8.1001
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发表时间：
2007-08-01
影响因子：
--
通讯作者：
Brenner, Sarah
中科院分区：
文献类型：
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作者：
Mashiah, Jacob;Wohl, Yonit;Brenner, Sarah
目的：探讨黑色素瘤皮损附近或远处的红斑性皮疹是否与血管内皮生长因子和/或血小板源性内皮细胞生长因子有关。方法：采用免疫组织化学方法检测13例原发性黑色素瘤组织中血管内皮生长因子和血小板源性内皮细胞生长因子的表达，其中6例有红斑疹，7例无红疹。结果：血管内皮生长因子在6例黑色素瘤伴红肿(Brenner征)患者中阳性表达3例(50%)，在7例无红肿的黑色素瘤患者中阳性表达4例(57%)。血小板衍化内皮细胞生长因子在6例黑色素瘤伴红肿患者中全部阳性(100%)，在7例黑色素瘤患者中阳性表达4例(57%)。结论：血小板衍化内皮细胞生长因子可能通过影响血管功能而参与黑色素瘤患者红斑的发病机制。
Objective: To assess whether an erythematous eruption in the vicinity of or distant from a melanoma lesion might be related to the vascular endothelial growth factor, the platelet-derived endothelial cell growth factor, or both.Methods: Biopsy specimens from 13 patients with primary melanoma, 6 of whom had erythematous eruptions and 7 who did not, were studied by immunohistochemistry for the expression of vascular endothelial growth factor and platelet-derived endothelial cell growth factor.Results: Vascular endothelial growth factor was positive in 3 of 6 patients (50%) with melanoma and redness (Brenner sign) and in 4 of 7 patients (57%) with melanoma without redness. Platelet-derived endothelial cell growth factor was positive in all 6 patients (100%) with melanoma and redness and in 4 of 7 patients (57%) with melanoma without redness.Conclusion: Platelet-derived endothelial cell growth factor may have a part in the pathogenesis of the redness observed in patients with melanoma, called Brenner sign, by affecting vasculature function.