The Causes, Treatment, and Outcome of Acute Heart Failure in 1006 Africans From 9 Countries Results of the Sub-Saharan Africa Survey of Heart Failure
The Causes, Treatment, and Outcome of Acute Heart Failure in 1006 Africans From 9 Countries Results of the Sub-Saharan Africa Survey of Heart Failure
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DOI：
10.1001/archinternmed.2012.3310
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发表时间：
2012-10-08
影响因子：
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通讯作者：
Sliwa, Karen
中科院分区：
文献类型：
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作者：
Damasceno, Albertino;Mayosi, Bongani M.;Sliwa, Karen
背景：急性心力衰竭（AHF）在撒哈拉以南非洲没有很好的特征。因此，我们试图描述撒哈拉以南非洲AHF患者入院的特征、治疗和结果。方法：撒哈拉以南非洲心力衰竭调查（THESUS-HF）是一项前瞻性、多中心、观察性调查，调查对象是9个国家12所大学医院的AHF患者。在AHF患者中，我们在6个月的随访中确定了病因、治疗方法和结果。结果：从2007年7月1日至2010年6月30日，我们入组了1006例AHF患者。平均（SD）年龄为52.3（18.3）岁，女性511(50.8%)，主要种族为非洲黑人（984 / 999[98.5%]）。平均（SD）左室射血分数为39.5%（16.5%）。心力衰竭最常见的原因是高血压（n=453[45.4%]）和风湿性心脏病（n=143[14.3%]）。缺血性心脏病（n=77[7.7%]）不是AHF的常见原因。并发肾功能不全(估计肾小球滤过率，
Background: Acute heart failure (AHF) in sub-Saharan Africa has not been well characterized. Therefore, we sought to describe the characteristics, treatment, and outcomes of patients admitted with AHF in sub-Saharan Africa.Methods: The Sub-Saharan Africa Survey of Heart Failure (THESUS-HF) was a prospective, multicenter, observational survey of patients with AHF admitted to 12 university hospitals in 9 countries. Among patients presenting with AHF, we determined the causes, treatment, and outcomes during 6 months of follow-up.Results: From July 1, 2007, to June 30, 2010, we enrolled 1006 patients presenting with AHF. Mean (SD) age was 52.3 (18.3) years, 511 (50.8%) were women, and the predominant race was black African (984 of 999 [98.5%]). Mean (SD) left ventricular ejection fraction was 39.5% (16.5%). Heart failure was most commonly due to hypertension (n=453 [45.4%]) and rheumatic heart disease (n=143 [14.3%]). Ischemic heart disease (n=77 [7.7%]) was not a common cause of AHF. Concurrent renal dysfunction (estimated glomerular filtration rate,