Sex differences in oxytocin and vasopressin: Implications for autism spectrum disorders?
Sex differences in oxytocin and vasopressin: Implications for autism spectrum disorders?
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DOI：
10.1016/j.bbr.2006.08.025
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发表时间：
2007-01-10
影响因子：
2.7
通讯作者：
Carter, C. Sue
中科院分区：
文献类型：
--
作者：
Carter, C. Sue
自闭症谱系障碍 (ASD) 偏向男性，其特征是社会行为和社交沟通缺陷、过度焦虑或对压力经历过度反应以及重复倾向。本综述的目的是考虑两种性二态性神经肽（催产素 (OT) 和精氨酸加压素 (VP)）在自闭症谱系障碍（ASD）这些特征中的作用证据。 VP和OT都在正常发育中发挥作用。 VP 依赖于雄激素，对男性行为尤其重要。 VP 过多或 VP 系统中断可能会导致男性更容易患自闭症谱系障碍 (ASD)。另外，通过 OT 或 OT 受体介导的保护过程可能有助于解释女性自闭症谱系障碍相对罕见的发生。 OT 或 VP 或其受体的破坏可能是由遗传变异或基因表达的表观遗传修饰引起的，特别是在早期发育期间。其他发育生长因子（例如 reelin）的缺陷，可能反过来调节 OT 或 VP 或受 OT 或 VP 调节，是在自闭症谱系障碍中发挥作用的其他候选因素。 (c) 2006 Elsevier B.V. 保留所有权利。
Autism spectrum disorders (ASD) are male-biased and characterized by deficits in social behavior and social communication, excessive anxiety or hyperreactivity to stressful experiences, and a tendency toward repetitiveness. The purpose of this review is to consider evidence for a role for two sexually dimorphic neuropeptides, oxytocin (OT) and arginine vasopressin (VP), in these features of ASD. Both VP and OT play a role in normal development. VP is androgen-dependent and of particular importance to male behavior. Excess VP or disruptions in the VP system could contribute to the male vulnerability to ASD. Alternatively, protective processes mediated via OT or the OT receptor might help to explain the relatively rare occurrence of ASD in females. Disruptions in either OT or VP or their receptors could result from genetic variation or epigenetic modifications of gene expression, especially during early development. Deficits in other developmental growth factors, such as reelin, which may in turn regulate or be regulated by OT or VP, are additional candidates for a role in ASD. (c) 2006 Elsevier B.V. All rights reserved.