Should Most Patients With Optic Neuritis be Tested for Neuromyelitis Optica Antibodies and Should This Affect Their Treatment?
Should Most Patients With Optic Neuritis be Tested for Neuromyelitis Optica Antibodies and Should This Affect Their Treatment?
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DOI：
10.1097/wno.0b013e3181f68c19
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发表时间：
2010-12-01
影响因子：
2.9
通讯作者：
Cornblath, Wayne T.
中科院分区：
文献类型：
--
作者：
Galetta, Steven L.;Cornblath, Wayne T.
视神经肌萎缩症（NMO）抗体（水通道蛋白-4抗体）可以进行常规检测，并已成为NMO的主要诊断标准（1-4）。这些抗体最近在没有任何神经症状且不符合NMO诊断标准的孤立性视神经炎患者中进行了描述（3-5）。然而，最近的研究表明，与NMO抗体阴性的患者相比，NMO抗体阳性的孤立性视神经炎患者的视力预后更差，复发率更高（5，6）。NMO抗体阳性的孤立性视神经炎也可能是NMO的首发症状（3-8）。然而，目前还不清楚是否NMO抗体应定期测试在一些或大多数孤立性视神经炎患者。事实上，是否积极的NMO抗体滴度影响孤立性视神经炎患者的管理仍然存在争议。
Neuromyelitis optica (NMO) antibodies (aquaporin-4 antibodies) can be routinely tested and have become a major diagnostic criteria for NMO (1-4). These antibodies have recently been described in patients with isolated optic neuritis who do not have any neurologic symptoms and who do not fulfill the diagnostic criteria for NMO (3-5). However, recent studies have suggested that patients with isolated optic neuritis who have positive NMO antibody have a worse visual prognosis and more recurrences than those who are negative for NMO antibodies (5,6). Isolated optic neuritis with positive NMO antibodies might also be the first sign of NMO (3-8). However, it is still unclear whether NMO antibodies should be routinely tested in some or most patients with isolated optic neuritis. Indeed, whether positive NMO antibodies titers affect the management of patients with isolated optic neuritis remains debated.