Amphiphilic γ-cyclodextrin?fullerene complexes with photodynamic activity
Amphiphilic γ-cyclodextrin?fullerene complexes with photodynamic activity
复制标题
具有光动力活性的两亲性γ-环糊精·富勒烯配合物
DOI：
10.1039/d1ma00743b
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发表时间：
2022
影响因子：
5
通讯作者：
Ohe Kouichi
中科院分区：
文献类型：
--
作者：
Miki Koji;Dan Zhang Zi;Kaneko Kaho;Kakiuchi Yui;Kojima Kentaro;Enomoto Akane;Oe Masahiro;Nogita Kohei;Murata Yasujiro;Harada Hiroshi;Ohe Kouichi
以亲脂性尾接γ-环糊精（γ-CD）、亲水性尾接γ-CD和富勒烯C60为原料，采用高速振动研磨法制备了两亲性γ-环糊精-富勒烯2：1复合物（CLFCH复合物）。 具有两个氨基的γ-CD-富勒烯复合物与亲脂性和亲水性活化酯的转酰胺作用也得到两亲性CLFCH复合物。由两亲性CLFCH复合物组成的自组装体在光照射下有效地产生单线态氧。在可见光照射条件下，CLFCH配合物轴承维生素E部分作为亲脂性尾部显示出高的光动力活性对癌细胞。
Amphiphilic γ-cyclodextrin–fullerene 2 : 1 complexes (CLFCH complexes) were prepared by high-speed vibration milling of lipophilic tail-grafted γ-cyclodextrin (γ-CD), hydrophilic tail-grafted γ-CD and fullerene C60. The transamidation of γ-CD–fullerene complexes having two amino groups with lipophilic and hydrophilic activated esters also afforded amphiphilic CLFCH complexes. Self-assemblies consisting of amphiphilic CLFCH complexes efficiently generated singlet oxygen under photoirradiation. Under visible light irradiation conditions, CLFCH complexes bearing a vitamin E moiety as a lipophilic tail showed high photodynamic activity toward cancer cells.