The Caenorhabditis elegans gene lin-26 is required to specify the fates of hypodermal cells and encodes a presumptive zinc-finger transcription factor.
The Caenorhabditis elegans gene lin-26 is required to specify the fates of hypodermal cells and encodes a presumptive zinc-finger transcription factor.
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发表时间：
1994-09
期刊：
影响因子：
4.6
通讯作者：
M. Labouesse;S. Sookhareea;H. Horvitz
中科院分区：
文献类型：
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作者：
M. Labouesse;S. Sookhareea;H. Horvitz
突变 lin-26(n156) 通过将外阴前体细胞转化为神经元或神经母细胞来阻止线虫外阴的形成。我们分离并鉴定了三个新的 lin-26 等位基因，它们会导致胚胎致死。这些突变导致一些其他皮下细胞表达神经命运，而大多数皮下细胞退化。 lin-26 编码假定的锌指转录因子。我们的数据表明，细胞获得皮下命运需要 lin-26。
The mutation lin-26(n156) prevents vulva formation in C. elegans by transforming the vulval precursor cells into neurons or neuroblasts. We have isolated and characterized three new lin-26 alleles, which result in embryonic lethality. These mutations cause a few other hypodermal cells to express a neural fate and most hypodermal cells to degenerate. lin-26 encodes a presumptive zinc-finger transcription factor. Our data indicate that lin-26 is required for cells to acquire the hypodermal fate.