The difference in NR-cell activity between patients with non-Hodgkin's lymphomas and Hodgkin's disease
The difference in NR-cell activity between patients with non-Hodgkin's lymphomas and Hodgkin's disease
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DOI：
10.1046/j.1365-2141.1999.01129.x
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发表时间：
1999-01-01
影响因子：
6.5
通讯作者：
Spuzic, I
中科院分区：
文献类型：
--
作者：
Konjevic, G;Jurisic, V;Spuzic, I
自然杀伤（NK）细胞在恶性疾病的免疫监视中起重要作用。考虑到恶性淋巴瘤的淋巴起源，以及关于NK细胞在这些肿瘤中的功能的缺乏数据，我们评估了49例非霍奇金淋巴瘤（NHL）和47例霍奇金病（HD）患者治疗前的NK细胞活性。采用推荐的国际工作公式和安阿伯淋巴瘤分期系统，我们发现，通过LDH释放细胞毒性试验，NK细胞活性降低（P
Natural killer (NK) cells play an important role in immune surveillance against malignant diseases. Considering the lymphoid origin of malignant lymphomas, as well as scarce data concerning NK-cell function in these neoplasms, we evaluated NK-cell activity in 49 patients with non-Hodgkin's lymphomas (NHL) and 47 patients with Hodgkin's disease (HD), prior to therapy. Using the recommended International Working Formulation and the Ann Arbor staging system for classification of lymphomas we found, by the LDH release cytotoxicity assay, that decreased NK-cell activity (P