Olfactory anhedonia and negative olfactory alliesthesia in depressed patients
Olfactory anhedonia and negative olfactory alliesthesia in depressed patients
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DOI：
10.1016/j.psychres.2008.11.016
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发表时间：
2010-04-30
影响因子：
11.3
通讯作者：
Camus, Vincent
中科院分区：
文献类型：
--
作者：
Atanasova, Boriana;El-Hage, Wissam;Camus, Vincent
本研究旨在探讨抑郁症患者的嗅觉快感缺乏和嗅觉负性联觉。两种气味，一个愉快的（香草醛），一个不愉快的（丁酸）享乐价进行了评估，由30名抑郁症住院患者和30名对照组（健康受试者，年龄和性别相匹配）。参与者探讨了16种不同刺激（3种浓度的气味剂，它们的9种组合，和1种含有蒸馏水的对照）的享乐价，强度（歧视）和感知质量（识别）。享乐知觉表明，患者认为不愉快的气味显着更不愉快比对照组（嗅觉负alliesthesia）。关于强度等级，控制能够区分所有浓度的气味，而患者区分不同浓度之间的不愉快的成分，而不是香草醛（嗅觉快感缺失）。关于在一个等强度的未混合的气味混合物的识别任务，患者认为愉快的气味比不愉快的（嗅觉快感缺失）显着减少，而控制认为这两种气味同样好。这些结果支持了抑郁症患者存在嗅觉障碍的观点。需要进一步的研究来复制这些发现，并确认这种嗅觉快感缺失或/和嗅觉负性联觉可能是抑郁症的一种状态或特征。(C)2008爱思唯尔爱尔兰有限公司保留所有权利。
The present study aimed to investigate olfactory anhedonia and olfactory negative alliesthesia in depressed patients. Two odorants, one with pleasant (vanillin), and one with unpleasant (butyric acid) hedonic valence were evaluated by 30 depressed inpatients and 30 controls (healthy subjects, matched by age and gender). Participants explored the hedonic valence, intensity (discrimination) and perceived quality (identification) of 16 different stimuli (3 concentrations of odorants, their 9 combinations, and 1 control containing distilled water). The hedonic perception showed that patients perceived the unpleasant odorant as significantly more unpleasant than controls (olfactory negative alliesthesia). Concerning the intensity ratings, controls were able to discriminate between all concentrations of odorants, while patients discriminated between the different concentrations only for the unpleasant component and not for the vanillin (olfactory anhedonia). Regarding the identification task in an iso-intense unmixed odorants mixture, patients perceived significantly less the pleasant odorant than the unpleasant one (olfactory anhedonia), whereas controls perceived both odorants equally well. These results support the notion of an olfactory perception impairment in depression. Further studies are needed to replicate these findings and to confirm that such olfactory anhedonia or/and olfactory negative alliesthesia could be a state or a trait of depression. (C) 2008 Elsevier Ireland Ltd. All rights reserved.