Higher Acute Insulin Response to Glucose May Determine Greater Free Fatty Acid Clearance in African-American Women
Higher Acute Insulin Response to Glucose May Determine Greater Free Fatty Acid Clearance in African-American Women
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DOI：
10.1210/jc.2011-0532
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发表时间：
2011-08-01
影响因子：
5.8
通讯作者：
Sumner, Anne E.
中科院分区：
文献类型：
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作者：
Chow, Carson C.;Periwal, Vipul;Sumner, Anne E.
背景：肥胖和糖尿病在非洲裔美国人中比白人更常见。由于游离脂肪酸（FFA）参与这些条件的发展，研究胰岛素调节FFA和葡萄糖的种族差异是必不可少的。目的：本研究的目的是确定葡萄糖和FFA对胰岛素的反应是否存在种族差异。设计：这是一项横断面研究。设置：本研究在临床研究中心进行。参与者：34名绝经前女性（17名非裔美国人，17名白人）年龄匹配[36 +/- 10岁（平均值+/- SD）]和体重指数（30.0 +/- 6.7公斤/米（2））。胰岛素修饰的频繁采样的静脉葡萄糖耐量试验进行了数据分析的葡萄糖和游离脂肪酸的单独的最小模型。葡萄糖测量为胰岛素敏感性指数（S-I）和急性胰岛素对葡萄糖的反应（AIRg）。结果：非裔美国人的体重指数与白人相似，但脂肪量高于白人（P < 0.01）。与白人相比，非裔美国人的S-I较低（3.71 +/- 1.55 vs. 5.23 +/- 2.74 [x10（-4）min（-1）/（microunits per ml）]（P = 0.05），AIRg较高（642 +/- 379 vs. 263 +/- 206 mU/l（-1）.min，P < 0.01）。校正脂肪量后，非裔美国人的FFA清除率c（f）较高（0.13 +/- 0.06 vs. 0.08 +/- 0.05 min（-1），P < 0.01）。调整AIRg后，c（f）的种族差异不再存在（P = 0.51）。在所有女性中，cf与AIRg有显著相关性（r = 0.64，P < 0.01），而c（f）与S-I无显著相关性（r =-0.07，P = 0.71）。同样的模式仍然存在时，两组studiedseparately.Conclusion：非洲裔美国妇女比白色妇女更胰岛素抵抗，但他们有更大的FFA清除。非洲裔美国妇女的胰岛素浓度明显较高，FFA清除率较高。（临床内分泌代谢杂志96：2456-2463，2011）
Context: Obesity and diabetes are more common in African-Americans than whites. Because free fatty acids (FFA) participate in the development of these conditions, studying race differences in the regulation of FFA and glucose by insulin is essential.Objective: The objective of the study was to determine whether race differences exist in glucose and FFA response to insulin.Design: This was a cross-sectional study.Setting: The study was conducted at a clinical research center.Participants: Thirty-four premenopausal women (17 African-Americans, 17 whites) matched for age [36 +/- 10 yr (mean +/- SD)] and body mass index (30.0 +/- 6.7 kg/m(2)).Interventions: Insulin-modified frequently sampled iv glucose tolerance tests were performed with data analyzed by separate minimal models for glucose and FFA.Main Outcome Measures: Glucose measures were insulin sensitivity index (S-I) and acute insulin response to glucose (AIRg). FFA measures were FFA clearance rate (c(f)).Results: Body mass index was similar but fat mass was higher in African-Americans than whites (P < 0.01). Compared with whites, African-Americans had lower S-I (3.71 +/- 1.55 vs. 5.23 +/- 2.74 [x 10(-4) min(-1)/(microunits per milliliter)] (P = 0.05) and higher AIRg (642 +/- 379 vs. 263 +/- 206 mU/liter(-1).min, P < 0.01). Adjusting for fat mass, African-Americans had higher FFA clearance, c(f) (0.13 +/- 0.06 vs. 0.08 +/- 0.05 min(-1), P < 0.01). After adjusting for AIRg, the race difference in c(f) was no longer present (P = 0.51). For all women, the relationship between cf and AIRg was significant (r = 0.64, P < 0.01), but the relationship between c(f) and S-I was not (r = -0.07, P = 0.71). The same pattern persisted when the two groups were studied separately.Conclusion: African-American women were more insulin resistant than white women, yet they had greater FFA clearance. Acutely higher insulin concentrations in African-American women accounted for higher FFA clearance. (J Clin Endocrinol Metab 96: 2456-2463, 2011)