Early-life factors and adult anti-Müllerian hormone levels.
Early-life factors and adult anti-Müllerian hormone levels.
复制标题
早期生命因素和成人抗苗勒氏管激素水平。
DOI：
10.1007/s10815-021-02281-3
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发表时间：
2021
影响因子：
3.1
通讯作者：
Hochner,Hagit
中科院分区：
文献类型：
--
作者：
Dior,UriPinchas;Karavani,Gilad;Soloveichick,Valerie;Friedlander,Yechiel;Hochner,Hagit
AimThis研究的目的是检查是否与成人卵巢储备，抗苗勒管激素（AMH）levels.MethodsThe工作是基于耶路撒冷围产期研究（JPS），一个广泛的出生队列，所有的怀孕和分娩的详细信息在耶路撒冷之间的1974年和1976年。一部分人参加了2007年至2009年的一项后续研究，他们在平均年龄32岁时完成了问卷调查并接受了身体检查。此外，还从每位参与者身上抽取了血液样本，并在239名女性样本中测量了AMH。以32岁时的AMH水平评估各早期生活因素（包括出生体重、母亲孕前体重、妊娠期体重增加（GWG）、出生时的社会经济地位和父母孕期吸烟）之间的关系。结果低出生体重与32岁时较低的AMH水平所反映的卵巢储备功能降低显著相关（范围30-36），独立于其他早期生活因素，调整混杂因素后（β= 0.180，p = 0.03）。根本机制尚待充分了解。
AimThis study aims to examine whether early-life factors are associated with adult ovarian reserve, measured by anti-Müllerian hormone (AMH) levels.MethodsThe work is based on the Jerusalem Perinatal Study (JPS), an extensive birth cohort with detailed information on all pregnancies and deliveries in Jerusalem between 1974 and 1976. A subset of individuals participated in a follow-up study that took place between 2007 and 2009 in which they completed questionnaires and were physically examined at mean age of 32. A blood sample was additionally drawn from each participant, and AMH was measured in a sample of 239 women. The associations between each early-life factors, including birth weight, maternal pre-pregnancy weight, gestational weight gain (GWG), socioeconomic position at birth, and parental smoking during pregnancy, were assessed with AMH levels at the age of 32.Multivariable regression models were used to examine the associations with AMH, adjusting for potential confounders at birth and at the age of 32.ResultsLow birth weight was significantly associated with lower ovarian reserve reflected by lower levels of AMH at age 32 (range 30–36), independent of other early-life factors and after adjusting for confounders (β= 0.180,p= 0.03).ConclusionsThis prospective study demonstrates the association of birth weight and adult ovarian reserve. Underlying mechanisms are yet to be fully understood.