The yeast frameshift suppressor gene SUF16-1 encodes an altered glycine tRNA containing the four-base anticodon 3'-CCCG-5'.
The yeast frameshift suppressor gene SUF16-1 encodes an altered glycine tRNA containing the four-base anticodon 3'-CCCG-5'.
复制标题
酵母移码抑制基因 SUF16-1 编码含有四碱基反密码子 3-CCCG-5 的改变的甘氨酸 tRNA。
DOI：
10.1016/0378-1119(82)90002-6
复制
发表时间：
1982
期刊：
影响因子：
3.5
通讯作者：
Culbertson,MR
中科院分区：
文献类型：
--
作者：
Gaber,RF;Culbertson,MR
Sufi 6移码抑制基因座编码甘氨酸tRNA。通过DNA序列分析推测，SUF16-1抑制子tRNA含有4个碱基的反密码子序列3‘-CCCG-5’，而不是野生型反密码子3‘-CCG-5’。SUF16-1介导四个碱基的信使RNA(MRNA)序列5‘-GGGU-3’的翻译，但显然不能作用于序列5‘-GGGG-3’。提出了一个分子模型，解释了tRNA介导的移码抑制在酿酒酵母中的观察到的特异性。
The SUFI 6 frameshift suppressor locus encodes a glycine tRNA. TheSUF16-1 suppressor tRNA is inferred by DNA sequence analysis to contain the four-base anticodon sequence 3'-CCCG-5' in place of the wild-type anticodon 3'-CCG-5'. SUF16-1 mediates translation of the four-base messenger RNA (mRNA) sequence 5'-GGGU-3' but apparently fails to act at the sequence 5'-GGGG-3'. A molecular model is presented that accounts for the observed specificity of tRNA-mediated frameshift suppression inSaccharomyces cerevisiae.