Brain tissue damage in dementia with Lewy bodies:: an in vivo diffusion tensor MRI study
Brain tissue damage in dementia with Lewy bodies:: an in vivo diffusion tensor MRI study
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DOI：
10.1093/brain/awh493
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发表时间：
2005-07-01
期刊：
影响因子：
14.5
通讯作者：
Nemni, R
中科院分区：
文献类型：
--
作者：
Bozzali, M;Falini, A;Nemni, R
本研究的目的是将扩散张量成像(DT-MRI)这一反映组织结构的定量MRI指标应用于路易体痴呆(DLB)。DT-MRI扫描来自15名可能患有DLB的患者和10名性别和年龄匹配的健康对照。与对照组相比，患者的胼胝体、距骨周区和额叶、顶叶、枕叶以及不太明显的颞叶白质均有异常。尾状核和壳核也有异常。患者组的平均灰质体积低于对照组。这些伴随灰质萎缩和白质异常的发现(如DT-MRI检测到的)位于长连接纤维束的高发区，可能提示存在涉及关联皮质的神经退行性变。颞叶的适度参与与DLB早期整体神经心理测量和记忆任务的相对保存相吻合。顶叶、额叶和枕叶的选择性受累可能解释了DLB的一些临床和神经心理学特征，为该病提供了一个可能的独特标志物。皮质下灰质中发现的异常可能表明DLB和帕金森病有相似的黑质纹状体受累，这是由共同的病理生理机制引起的。
The aim of the present study was to apply diffusion tensor MRI (DT-MRI), a quantitative MRI measure which reflects tissue organization, to dementia with Lewy bodies (DLB). DT-MRI scans were obtained from 15 patients with probable DLB and 10 sex- and age-matched healthy controls. Abnormalities were found in the corpus callosum, pericallosal areas and the frontal, parietal, occipital and, less prominently, temporal white matter of patients compared with controls. Abnormalities were also found in the caudate nucleus and the putamen. The average grey matter volume was lower in patients than in controls. These findings of concomitant grey matter atrophy and white matter abnormalities (as detected by DT-MRI) in regions with a high prevalence of long connecting fibre tracts might suggest the presence of neurodegeneration involving associative cortices. The modest involvement of the temporal lobe fits with the relative preservation of global neuropsychological measures and memory tasks in the early stage of DLB. The selective involvement of parietal, frontal and occipital lobes might explain some of the clinical and neuropsychological features of DLB, providing a possible distinctive marker for this disease. The abnormalities found in the subcortical grey matter may indicate that DLB and Parkinson's disease share a similar nigrostriatal involvement caused by common pathophysiological mechanisms.