Monitoring the penetration enhancer dimethyl sulfoxide in human stratum corneum in vivo by confocal Raman spectroscopy
Monitoring the penetration enhancer dimethyl sulfoxide in human stratum corneum in vivo by confocal Raman spectroscopy
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DOI：
10.1023/a:1020481305420
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发表时间：
2002-10-01
影响因子：
3.7
通讯作者：
Puppels, GJ
中科院分区：
文献类型：
--
作者：
Caspers, PJ;Williams, AC;Puppels, GJ
角质层（SC）屏障通常由嵌入脂质连续体中的角质细胞层组成，脂质连续体调节屏障功能。含有神经酰胺、胆固醇和游离脂肪酸的脂质结构域为大多数药物通过SC提供了主要途径(1)。穿透增强剂削弱SC屏障功能。经典的增强剂是二甲基亚砜（DMSO）(2)。其作用机制尚不清楚，尽管DMSO破坏脂质组织并可能取代蛋白质结合水(3)。
The stratum corneum (SC) barrier typically consists of layers of corneocytes embedded in a lipid continuum that regulates barrier function. The lipid domain containing ceramides, cholesterol, and free fatty acids provides the major pathway for most drugs permeating across SC (1). Penetration enhancers diminish the SC barrier function. The classic enhancer is dimethyl sulfoxide (DMSO)(2). Its mechanisms of action remain unclear, although DMSO disrupts lipid organisation and may displace protein-bound water (3).