Red blood cell distribution width: a potential laboratory parameter for monitoring inflammation in rheumatoid arthritis
Red blood cell distribution width: a potential laboratory parameter for monitoring inflammation in rheumatoid arthritis
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红细胞分布宽度：监测类风湿性关节炎炎症的潜在实验室参数
DOI：
10.1007/s10067-017-3871-7
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发表时间：
2018-01-01
影响因子：
3.4
通讯作者：
Ou, Qishui
中科院分区：
文献类型：
--
作者：
He, Yujue;Liu, Can;Ou, Qishui
通过对类风湿关节炎（RA）患者红细胞分布宽度（RDW）与C反应蛋白（CRP）、血沉（ESR）、肿瘤坏死因子-α（TNF-α）、白细胞介素（IL）-6、IL-10的相关性分析，探讨RDW是否可作为RA患者炎症反应的潜在指标。2014年10月至2016年4月，共有670例RA患者入组本研究。回顾性分析RA患者外周血白色细胞（WBC）、红细胞（RBC）、血小板（PLT）、血红蛋白（HGB）、RDW、CRP、ESR。通过RT-qPCR检测TNF-α、IL-6和IL-10的相对表达。用Excel软件对RA患者RDW与CRP、ESR、TNF-α、IL-6、IL-10进行相关性分析。RA患者的RDW水平显著高于骨关节炎（OA）患者（P < 0.001）和健康献血员（HD）（P < 0.001），并且RDW与炎症标志物如CRP和ESR呈正相关。在ROC曲线分析中，用于识别RA的RDW的曲线下面积（AUC）为0.881，95%置信区间（CI）为0.864至0.898。相关分析显示RDW水平与TNF-α、IL-6呈正相关，与IL-10呈负相关。RDW在RA患者中增高，与RA的炎症反应有关，提示RDW可能是一个方便地反映RA炎症反应的潜在辅助指标。
Correlation analysis of red blood cell distribution width (RDW) and C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-6, and IL-10 in rheumatoid arthritis (RA) to investigate whether RDW can serve as a potential parameter for indicating inflammation in RA patients. A total of 670 RA patients from October 2014 to April 2016 were enrolled in our study. The white blood cell (WBC), red blood cell (RBC), platelet (PLT), hemoglobin (HGB), RDW, CRP, and ESR in peripheral blood of patients with RA were retrospectively analyzed. The relative expression of TNF-alpha, IL-6, and IL-10 was detected by RT-qPCR. Correlation analysis between RDW and CRP, ESR, TNF-alpha, IL-6, and IL-10 in RA was conducted by Microsoft Excel. RDW level was significantly increased in RA patients compared to osteoarthritis (OA) patients (P < 0.001) and healthy donors (HDs) (P < 0.001), and RDW was positively associated with inflammatory markers, such as CRP and ESR. In ROC curve analysis, the area under the curve (AUC) of RDW for the identification of RA was 0.881, with a 95% confidence interval (CI) from 0.864 to 0.898. Moreover, correlation analysis showed that RDW level was positively associated with TNF-alpha and IL-6, however negatively associated with IL-10. RDW was increased in patients with RA which was associated with inflammation in RA, suggesting that RDW may be a potential auxiliary marker for indicating inflammation process in RA conveniently.