A forced expiratory flow at 25-75% value <65% of predicted should be considered abnormal: A real-world, cross-sectional study
A forced expiratory flow at 25-75% value <65% of predicted should be considered abnormal: A real-world, cross-sectional study
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DOI：
10.2500/aap.2012.33.3524
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发表时间：
2012-01-01
影响因子：
2.8
通讯作者：
La Rosa, Mario
中科院分区：
文献类型：
--
作者：
Ciprandi, Giorgio;Capasso, Michele;La Rosa, Mario
1秒用力呼气量(FEV1)被认为是哮喘诊断和随访的重要参数。然而，有人认为，25-75%的用力呼气流量(FEF25-75)可能比FEV1更敏感地发现轻微的呼吸道阻塞。在这方面，最近在一组哮喘儿童中建立了FEF25-75的分界值：FEF25-75&65%的预测值被认为是受损的。然而，所考虑的人群是特别选定的。因此，本研究的目的是在一大批哮喘儿童中确定FEF25-75的临界值。700名过敏性儿童(493名男性受试者，中位年龄，11岁)通过进行肺活量测定和皮肤点刺试验来评估控制和部分控制的哮喘。313例(44.7%)患者的FEF25-75%为预测值的65%。有两个预测因子与FEF25-75值受损显著相关：(I)对常年过敏原的敏化(调整后的优势比[ORAdj]，3.4)和(Ii)FEV1
Forced expiratory volume in 1 second (FEV1) is considered an important parameter for asthma diagnosis and follow-up. However, it has been proposed that forced expiratory flow at 25-75% (FEF25-75) could be more sensitive than FEV1 to detect slight airways obstruction. In this regard, a cutoff FEF25-75 value has been recently established in a group of asthmatic children: FEF25-75 < 65% of predicted has been considered impaired. However, the considered population was specifically selected. Therefore, the aim of the present study was to confirm an FEF25-75 cutoff value in a large cohort of asthmatic children. Seven hundred allergic children (493 male subjects; median age, 11 years) with controlled and partly controlled asthma were evaluated by performing spirometry and skin-prick tests. Three hundred thirteen (44.7%) patients had FEF25-75% values of < 65% of predicted. Two predictors were significantly associated with impaired FEF25-75 values: (i) sensitization to perennial allergens (adjusted odds ratio [ORAdj], 3.4) and (ii) FEV1