Cytoskeletal Remodeling in Cancer.
Cytoskeletal Remodeling in Cancer.
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DOI：
10.3390/biology9110385
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发表时间：
2020-11-07
期刊：
影响因子：
4.2
通讯作者：
Aseervatham J
中科院分区：
文献类型：
--
作者：
Aseervatham J
细胞迁移是从胚胎发生到细胞死亡的重要过程。这受到许多蛋白质的严格调控，这些蛋白质有助于细胞的正常运作。在癌症等疾病中，这一过程被解除调控，有助于肿瘤细胞从原发部位扩散到次要部位，从而启动转移过程。为了有效转移，细胞骨架成分如肌动蛋白、肌球蛋白和中间丝及其相关蛋白应有序协调，导致许多细胞突起的形成--如片状脂膜、丝状脂膜和内胚层。对这一过程的了解是控制癌细胞转移的关键，癌细胞转移导致90%的患者死亡。这篇综述的重点是对这些过程有一个全面的了解，集中在蛋白质结合和调节的变化以及肿瘤细胞如何利用它来发挥优势。由于细胞骨架蛋白的表达与肿瘤的恶性程度直接相关，对这些蛋白的了解将为改善癌症的预后和治疗提供强有力的工具。转移的成功依赖于细胞的侵袭、迁移、宿主免疫逃逸、外渗和血管生成。细胞的侵袭和迁移过程依赖于细胞骨架成分肌动蛋白、微管蛋白和中间丝的动态变化。这是可能的，因为细胞骨架的可塑性和所有三者的协调作用，是从原发部位转移的关键过程。由内部线索引起的细胞结构的改变将影响细胞的功能，导致不同的突起的形成，如片状脂膜、丝状脂膜和内突，这些突起帮助细胞迁移，最终导致转移，这比肿瘤的形成更危及生命。了解其中涉及的信号机制，将有助于更好地了解转移过程中的变化，最终将有助于靶向治疗蛋白质，从而降低死亡率和延长生存期。
Cell migration is an essential process from embryogenesis to cell death. This is tightly regulated by numerous proteins that help in proper functioning of the cell. In diseases like cancer, this process is deregulated and helps in the dissemination of tumor cells from the primary site to secondary sites initiating the process of metastasis. For metastasis to be efficient, cytoskeletal components like actin, myosin, and intermediate filaments and their associated proteins should co-ordinate in an orderly fashion leading to the formation of many cellular protrusions-like lamellipodia and filopodia and invadopodia. Knowledge of this process is the key to control metastasis of cancer cells that leads to death in 90% of the patients. The focus of this review is giving an overall understanding of these process, concentrating on the changes in protein association and regulation and how the tumor cells use it to their advantage. Since the expression of cytoskeletal proteins can be directly related to the degree of malignancy, knowledge about these proteins will provide powerful tools to improve both cancer prognosis and treatment. Successful metastasis depends on cell invasion, migration, host immune escape, extravasation, and angiogenesis. The process of cell invasion and migration relies on the dynamic changes taking place in the cytoskeletal components; actin, tubulin and intermediate filaments. This is possible due to the plasticity of the cytoskeleton and coordinated action of all the three, is crucial for the process of metastasis from the primary site. Changes in cellular architecture by internal clues will affect the cell functions leading to the formation of different protrusions like lamellipodia, filopodia, and invadopodia that help in cell migration eventually leading to metastasis, which is life threatening than the formation of neoplasms. Understanding the signaling mechanisms involved, will give a better insight of the changes during metastasis, which will eventually help targeting proteins for treatment resulting in reduced mortality and longer survival.
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DOI：
10.1158/1078-0432.ccr-08-1402
发表时间：
2009-02-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Bedolla RG;Wang Y;Asuncion A;Chamie K;Siddiqui S;Mudryj MM;Prihoda TJ;Siddiqui J;Chinnaiyan AM;Mehra R;de Vere White RW;Ghosh PM
通讯作者：
Ghosh PM
影响因子：
3.7
作者：
Al-Alwan M;Olabi S;Ghebeh H;Barhoush E;Tulbah A;Al-Tweigeri T;Ajarim D;Adra C
通讯作者：
Adra C
影响因子：
3.2
作者：
Arjonen, Antti;Kaukonen, Riina;Ivaska, Johanna
通讯作者：
Ivaska, Johanna
角蛋白8磷酸化的丧失导致肿瘤进展增加，并与OSCC患者的临床病理参数相关。
影响因子：
3.7
作者：
Alam H;Gangadaran P;Bhate AV;Chaukar DA;Sawant SS;Tiwari R;Bobade J;Kannan S;D'cruz AK;Kane S;Vaidya MM
通讯作者：
Vaidya MM
DOI：
10.1126/science.aay7794
发表时间：
2020-06-12
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bisaria A;Hayer A;Garbett D;Cohen D;Meyer T
通讯作者：
Meyer T