Induction of G2/M cell cycle arrest and apoptosis by a benz[f]indole-4,9-dione analog in cultured human lung (A549) cancer cells.
Induction of G2/M cell cycle arrest and apoptosis by a benz[f]indole-4,9-dione analog in cultured human lung (A549) cancer cells.
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DOI：
10.1016/j.bmcl.2004.07.062
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发表时间：
2004-10
影响因子：
2.7
通讯作者：
Eun-Jin Lee;Hyun-Jung Lee;H. Park;H. Min;M. Suh;Hwa-Jin Chung;S. Lee
中科院分区：
文献类型：
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作者：
Eun-Jin Lee;Hyun-Jung Lee;H. Park;H. Min;M. Suh;Hwa-Jin Chung;S. Lee
合成的苯并[f]吲哚-4，9-二酮类似物2-氨基-3-乙氧羰基-N-甲基苯并[f]吲哚-4，9-二酮（SME-6）显示出对一组人癌细胞系的有效生长抑制。作用机制研究表明，SME-6对人肺癌细胞（A549）的生长抑制作用与其诱导G2/M期细胞阻滞和凋亡密切相关。这些结果为进一步了解苯并[f]吲哚-4，9-二酮类化合物的抗肿瘤作用机制提供了新的信息。
A synthetic benz[f]indole-4,9-dione analog, 2-amino-3-ethoxycarbonyl-N-methylbenz[f]indole-4,9-dione (SME-6), showed a potent growth inhibition of a panel of human cancer cell lines. The mechanism of action study revealed that the growth inhibitory effect of SME-6 was highly related to the induction of G2/M cell cycle arrest and apoptosis in human lung cancer cells (A549). These data may provide new information for understanding the mechanisms by benz[f]indole-4,9-diones-mediated antitumor activity.