PERSONALITY AND PSYCHOPATHOLOGY - GENETIC PERSPECTIVES
PERSONALITY AND PSYCHOPATHOLOGY - GENETIC PERSPECTIVES
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DOI：
10.1037/0021-843x.103.1.32
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发表时间：
1994-02-01
影响因子：
4.6
通讯作者：
DILALLA, DL
中科院分区：
文献类型：
--
作者：
CAREY, G;DILALLA, DL
遗传因素对成年人的人格特质有重要影响，占变异的30%到60%。遗传对于大多数形式的精神病理学也很重要，并且在将人格与精神病理学联系起来的几种理论中起着重要作用。尽管如此，令人惊讶的是，关于人格和精神病理学联合分析的多变量遗传研究报告很少。现有的少量数据表明，基因可能占神经质与焦虑和抑郁状态症状之间观察到的相关性的50%以上。这种强烈的遗传相关性背后的机制对于理解人格特质和疾病之间的因果关系至关重要，因为受遗传影响的生物系统可能作为外源性“第三方”因素运作，这些因素对表型因果关系负责。我们说明了行为遗传学的最新分析进展如何使用多变量家庭数据来解决人格在精神病理学中的因果作用问题。
Genetic factors exert an important influence on adult personality traits, accounting for anywhere between 30% and 60% of the variance. Heredity is also important for most forms of psychopathology and plays a major role in several theories that relate personality to psychopathology. Despite this, there has been surprisingly little multivariate genetic research reported on joint analyses of personality and psychopathology. The small amount of available data suggests that genes may account for over 50% of the observed correlation between neuroticism and state symptoms of anxiety and depression. The mechanisms behind such strong genetic correlations are crucial for understanding the causal relationship between a personality trait and a disorder because genetically influenced biological systems may operate as exogenous ''third-party'' factors that are responsible for what appear to be phenotypic cause-effect relationships. We illustrate how recent analytical advances in behavior genetics can use multivariate family data to address questions about the causal role of personality in psychopathology.