Effects of Chronic Excess Salt Ingestion: Modification Of Experimental Hypertension In The Rat By Variations In The Diet
Effects of Chronic Excess Salt Ingestion: Modification Of Experimental Hypertension In The Rat By Variations In The Diet
复制标题
慢性过量盐摄入的影响：通过饮食变化改变大鼠实验性高血压
作者：
Lewis K. Dahl;K. Knudsen;M. Heine;G. Leitl
采用不同的技术手段，对可预测发生实验性高血压的大鼠品系进行了nacl诱导高血压的研究。除死亡干预外，断奶后继续观察1年。在NaCl含量分别为0.4、1、2、4和8%的各组大鼠中，血压普遍随饲料中NaCl含量的增加而升高。平均血压从最低组的146.8 mm Hg到最高盐摄入量组的210.2 mm Hg不等。发病率和死亡率也有所增加。即使是短暂的高盐饮食也能诱发永久性高血压；34只大鼠中有4只在断奶后仅2周内喂食8% NaCl，其血压为180至206毫米汞柱，尽管大多数大鼠的高血压程度并未明显高于喂食低（0.4%）NaCl的大鼠。在29只动物中，同样的饮食持续6周后，血压平均为198.6 mm Hg。高盐摄入量开始的年龄也影响高血压的病程。高盐日粮使断奶大鼠迅速发展为暴发性高血压。给药3个月后，平均血压超过200 mm Hg的大鼠40只，死亡或绝症动物35只。在大鼠中，当高盐饮食开始时，高血压发展得更慢，发作性也更少。在断奶后3或6个月才开始使用NaCl的38只大鼠中，NaCl 3个月后血压平均为175 ~ 180 mm Hg；31人健康状况良好，但没有一人存活8个月。
A strain of rats that will predictably develop experimental hypertension by means of different techniques was used to study NaCl-induced hypertension. Observations were continued for 1 year after weaning unless death intervened. Among groups of rats on 0.4, 1, 2, 4, and 8% NaCl chow, respectively, blood pressures generally rose as dietary NaCl increased. Average blood pressures ranged from 146.8 mm Hg in the group on the lowest, to 210.2 mm Hg in the group with the highest NaCl intakes. Morbidity and mortality also increased. Even transient high NaCl diets were capable of inducing permanent hypertension; 4 of 34 rats on 8% NaCl chow for only 2 weeks after weaning had pressures of 180 to 206 mm Hg, although most rats did not become significantly more hypertensive than those on the low (0.4%) NaCl diet. When this same diet was continued for a total of 6 weeks in a group of 29 animals, the blood pressure averaged 198.6 mm Hg. The age at which the high NaCl intake began also influenced the course of the hypertension. Weanling rats rapidly developed fulminating hypertension on the high NaCl diet. After 3 months on this regimen, the average pressure of 40 rats exceeded 200 mm Hg, and 35 animals were dead or terminally ill. In rats that were older when high NaCl diets were started, hypertension developed more slowly and was less fulminant. Among 38 rats in which NaCl was not begun until 3 or 6 months past weaning, blood pressures averaged 175 to 180 mm Hg after 3 months on NaCl; 31 appeared in good health but none survived 8 months.