Sympathetic Neural Overdrive in the Obese and Overweight State Meta-Analysis of Published Studies
Sympathetic Neural Overdrive in the Obese and Overweight State Meta-Analysis of Published Studies
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DOI：
10.1161/hypertensionaha.119.12885
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发表时间：
2019-08-01
期刊：
影响因子：
8.3
通讯作者：
Mancia, Giuseppe
中科院分区：
文献类型：
--
作者：
Grassi, Guido;Biffi, Annalisa;Mancia, Giuseppe
神经交通记录(肌肉交感神经交通[MSNA])表明，交感神经激活可能发生在肥胖患者身上。然而，现有研究的样本量小、存在并存、受试者的异质性是不能得出明确结论的主要弱点。这就是超重状态的情况。目前的荟萃分析评估了45项显微神经学研究中招募的1438名肥胖或超重受试者。该分析主要基于MSNA对肥胖和超重的量化，不包括高血压、代谢综合征和其他合并症。评估扩展到MSNA与其他神经肾上腺素能标记物的关系，如血浆去甲肾上腺素和心率，人体测量变量，如体重指数，腰臀比，有无阻塞性睡眠呼吸暂停，以及代谢谱。与正常体重组相比，超重组和肥胖组的MSNA显著增加(37.0+/-4.1对43.2+/-3.5和50.4+/-5.0 Burts/100次心跳，P
Nerve traffic recordings (muscle sympathetic nerve traffic [MSNA]) have shown that sympathetic activation may occur in obesity. However, the small sample size of the available studies, presence of comorbidities, heterogeneity of the subjects examined represented major weaknesses not allowing to draw definite conclusions. This is the case for the overweight state. The present meta-analysis evaluated 1438 obese or overweight subjects recruited in 45 microneurographic studies. The analysis was primarily based on MSNA quantification in obesity and overweight, excluding as concomitant conditions hypertension, metabolic syndrome, and other comorbidities. Assessment was extended to the relationships of MSNA with other neuroadrenergic markers, such as plasma norepinephrine and heart rate, anthropometric variables, as body mass index, waist-to-hip ratio, presence/absence of obstructive sleep apnea, and metabolic profile. Compared with normoweights MSNA was significantly greater in overweight and more in obese individuals (37.0 +/- 4.1 versus 43.2 +/- 3.5 and 50.4 +/- 5.0 burts/100 heartbeats, P