Cobalt-catalyzed hydrocyanation and hydroarylation of enamines
Cobalt-catalyzed hydrocyanation and hydroarylation of enamines
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DOI：
10.1016/j.tetlet.2019.151314
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发表时间：
2019-12-19
影响因子：
1.8
通讯作者：
Nishida, Atsushi
中科院分区：
文献类型：
--
作者：
Arai, Shigeru;Sato, Yuichi;Nishida, Atsushi
介绍了一种由钴（salen）配合物催化的温和、通用、高效的胺类氢氰化反应和氢芳基化反应。这两种反应都包括胺类化合物的区域选择性C-H键形成，相应的产物产率高。氢化芳基化反应在环化步骤中对氮上的苯甲酰环和苯甲酰环进行了严格的区分，并给出了相应的含季碳的异吲哚酮。(C) 2019 Elsevier Ltd.版权所有。
A mild, general and efficient hydrocyanation and hydroarylation of enamines catalyzed by Co(salen) complexes are described. Both reactions include regioselective C-H bond formation of enamines, and the corresponding products are obtained in high yield. Hydroarylation critically discriminates the benzyl and benzoyl aromatic rings on nitrogen in cyclization step, and the corresponding isoindolinones including quaternary carbons are exclusively given. (C) 2019 Elsevier Ltd. All rights reserved.