Expression of an endogenous retrovirus (ERV3 HERV-R) in human reproductive and embryonic tissues--evidence for a function for envelope gene products.
Expression of an endogenous retrovirus (ERV3 HERV-R) in human reproductive and embryonic tissues--evidence for a function for envelope gene products.
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内源性逆转录病毒（ERV3 HEV-R）在人类生殖和胚胎组织中的表达——包膜基因产物功能的证据。
DOI：
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发表时间：
1994
影响因子：
3.4
通讯作者：
B. Ove Nilsson
中科院分区：
文献类型：
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作者：
E. Larsson;A. Andersson;B. Ove Nilsson
ERV3 （HERV-R）是位于7号染色体长臂上的一种完整的人内源性逆转录病毒。它在几种人体组织中以LTR环境剪接转录本的形式表达（9和3.5 kb）。在胎盘中表达水平最高，在绒毛膜癌细胞系中表达水平下调。采用原位杂交技术，研究了ERV3 env在人生殖组织和胚胎组织中的表达。结果表明：(a) ERV3 env不仅在胎盘的合胞滋养细胞中表达，在包子痣和绒毛膜癌中也表达（无论来源如何）；(b) ERV3在胎盘中的表达与细胞融合有关，但可能与受精过程本身无关；(c) ERV3 env在精子发生的某些细胞中高表达，但在Sertoli或Leydig细胞中不表达。最后(d) ERV3 env在某些胚胎组织如肾上腺和神经组织中表达。
ERV3 (HERV-R) is a complete human endogenous retrovirus located on the long arm of chromosome 7. It is expressed in several human tissues as LTR env spliced transcripts (9 and 3.5 kb). The highest level of expression is to be found in placenta and virus expression is down-regulated in choriocarcinoma cell lines. By means of in situ hybridization, the expression of ERV3 env was studied in selected human reproductive and embryonic tissues. It is concluded that (a) ERV3 env is expressed in syncytiotrophoblasts not only in the placenta but also in hydatidiform moles and choriocarcinomas (irrespective of origin) (b) ERV3 expression in placenta correlates to cell fusion but probably not to the fertilization process itself (c) ERV3 env is highly expressed in certain cells in spermatogenesis but not in the Sertoli or Leydig cells, and finally (d) ERV3 env is expressed in certain embryonic tissues such as the adrenal gland and nervous tissues.