Chronic stress during prepubertal development: immediate and long-lasting effects on arterial blood pressure and anxiety-related behavior
Chronic stress during prepubertal development: immediate and long-lasting effects on arterial blood pressure and anxiety-related behavior
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DOI：
10.1016/s0306-4530(01)00092-0
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发表时间：
2002-07-01
影响因子：
3.7
通讯作者：
Markel, AL
中科院分区：
文献类型：
--
作者：
Maslova, LN;Bulygina, VV;Markel, AL
本研究旨在研究青春期前环境应激对遗传应激性动脉高血压（ISIAH）大鼠和正常Wistar大鼠血压（BP）水平和焦虑相关行为的直接和长期影响。使用两种慢性应激模型（出生后21-32天）：重复处理（HS）和不可预测应激（US）每天暴露于各种轻度身体或心理应激源。大鼠在慢性应激期结束后和4个月大时进行了测试。慢性青春期前应激不影响年轻或成年Wistar大鼠的基础或应激诱导的血压水平。在ISIAH大鼠中，高血压发展早期的慢性应激不会加速其形成，也不会增强其在成年期的表现。此外，与年龄匹配的对照组相比，暴露于HS或US的年轻和成年ISIAH大鼠的基础血压降低。急性应激对成人血压升高没有长期影响。在静息和急性应激条件下，经历过青春期前应激的成年大鼠血浆皮质酮水平没有变化。高血压大鼠在升高+迷宫测试中被证明焦虑程度较低。慢性应激对两大鼠的直接影响相似：HS具有抗焦虑作用，而US则刺激焦虑。长期影响取决于大鼠品系：HS在Wistar大鼠中保留了抗焦虑作用，而US在成年ISIAH大鼠中引起了更大的焦虑。数据没有证据表明焦虑症状与ISIAH大鼠应激敏感性高血压的发展和维持有关。(C) 2002 Elsevier Science Ltd.版权所有。
The present work was undertaken to study the immediate and long-lasting effects of environmental stress during prepubertal life in rats with inherited stress-induced arterial hypertension (ISIAH) and normotensive Wistar rats on blood pressure (BP) levels and anxiety-related behavior. Two models of chronic stress (21-32 postnatal days) were used: repeated handling (HS) and unpredictable stress (US) of daily exposures to a variety of mild physical or psychoemotional stressors. Rats were tested just after the end of the chronic stress period and then at the age of 4 months. Chronic prepubertal stress did not affect the basal or stress-induced BP levels in young or adult Wistar rats. In ISIAH rats, chronic stress during the early phase of hypertension development did not accelerate its formation and did not augment its manifestation in adults. Moreover, the basal BP was decreased in young and adult ISIAH rats exposed to HS or US as compared to the age-matched controls. No long-lasting effect on BP elevation under acute stress in adults was found. Plasma corticosterone levels at resting and acute stress conditions were not changed in adult rats that had experienced prepubertal stress. Hypertensive rats proved to be less anxious in the elevated plus-maze test. The immediate effects of chronic stress were similar in the two rat strains: HS had an anxiolytic action while US stimulated anxiety. Long-lasting consequences depended on the rat strain: the anxiolytic effect of HS was retained in Wistar rats and US caused a greater anxiety in adult ISIAH rats. The data do not evidence that symptoms of anxiety are related to the development and maintenance of stress-sensitive arterial hypertension in ISIAH rats. (C) 2002 Elsevier Science Ltd. All rights reserved.