Novel gene signature reveals prognostic model in acute lymphoblastic leukemia.
Novel gene signature reveals prognostic model in acute lymphoblastic leukemia.
复制标题
新的基因特征揭示了急性淋巴细胞白血病的预后模型
DOI：
10.3389/fcell.2022.1036312
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发表时间：
2022
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
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作者：
急性淋巴细胞白血病（ALL）是一种血液系统恶性肿瘤，预后较差。在我们的研究中，我们旨在通过鉴定与 ALL 预后密切相关的重要基因来构建 ALL 的预后模型。我们从 GDC TARGET 数据库中获取了所有样本的转录组数据 (RNA-seq)，并使用 R 软件的“DESeq”包识别了差异表达基因 (DEG)。我们使用单变量和多变量cox回归分析来筛选ALL的预后基因。在我们的结果中，风险评分可以作为预测 ALL 患者预后的独立预后因素 [风险比 (HR) = 2.782，95% CI = 1.903–4.068，p < 0.001]。临床参数中的风险评分对于预测ALL患者的总生存期具有较高的诊断敏感性和特异性，受试者工作特征（ROC）分析结果中的曲线下面积（AUC）为0.864。我们的研究评估了六个基因的潜在预后特征，并构建了一个与 ALL 患者预后显着相关的风险模型。本研究结果可帮助临床医生调整治疗方案，区分预后良好和不良的患者进行针对性治疗。
Acute lymphoblastic leukemia (ALL) is a type of hematological malignancy and has a poor prognosis. In our study, we aimed to construct a prognostic model of ALL by identifying important genes closely related to ALL prognosis. We obtained transcriptome data (RNA-seq) of ALL samples from the GDC TARGET database and identified differentially expressed genes (DEGs) using the “DESeq” package of R software. We used univariate and multivariate cox regression analyses to screen out the prognostic genes of ALL. In our results, the risk score can be used as an independent prognostic factor to predict the prognosis of ALL patients [hazard ratio (HR) = 2.782, 95% CI = 1.903–4.068, p < 0.001]. Risk score in clinical parameters has high diagnostic sensitivity and specificity for predicting overall survival of ALL patients, and the area under curve (AUC) is 0.864 in the receiver operating characteristic (ROC) analysis results. Our study evaluated a potential prognostic signature with six genes and constructed a risk model significantly related to the prognosis of ALL patients. The results of this study can help clinicians to adjust the treatment plan and distinguish patients with good and poor prognosis for targeted treatment.