Prevalence of chronic gastrointestinal symptoms in children with autism and autistic spectrum disorders
Prevalence of chronic gastrointestinal symptoms in children with autism and autistic spectrum disorders
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DOI：
10.1177/1362361303007002004
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发表时间：
2003-06-01
期刊：
影响因子：
5.2
通讯作者：
Manning-Courtney, P
中科院分区：
文献类型：
--
作者：
Molloy, CA;Manning-Courtney, P
这项研究的目的是评估自闭症或自闭症谱系障碍(ASD)儿童的一般人群中慢性胃肠道症状的患病率。研究地点是美国中西部一个大型儿科医疗中心的一家专门治疗自闭症的诊所，该中心服务于美国中西部的10个县地区。在137名年龄在24-96个月之间的儿童样本中，24%的儿童至少有一种慢性胃肠道症状，他们被自闭症诊断观察表-通用分类为患有自闭症或自闭症。最常见的症状是腹泻，发生率为17%。慢性胃肠道症状与发育退化史之间没有关联。讨论了自闭症和胃肠道症状之间潜在的表型联系。
The purpose of this study was to estimate the prevalence of chronic gastrointestinal symptoms in a general population of children with autism or autistic spectrum disorder (ASD). The study site was a clinic specializing in ASD in a large pediatric medical center serving a 10 county area in the midwestern USA. In a sample of 13 7 children, age 24-96 months, classified as having autism or ASD by the Autism Diagnostic Observation Schedule-Generic, 24 percent had a history of at least one chronic gastrointestinal symptom. The most common symptom was diarrhea, which occurred in 17 percent. There was no association between chronic gastrointestinal symptoms and a history of developmental regression. The potential phenotypic association between autism and gastrointestinal symptoms is discussed.