A REQUIREMENT FOR 2 CELL TYPES FOR ANTIBODY FORMATION IN VITRO
A REQUIREMENT FOR 2 CELL TYPES FOR ANTIBODY FORMATION IN VITRO
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DOI：
10.1126/science.158.3808.1573
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发表时间：
1967-01-01
期刊：
影响因子：
56.9
通讯作者：
MOSIER, DE
中科院分区：
文献类型：
--
作者：
MOSIER, DE
小鼠脾细胞的悬浮液可根据其粘附于塑料培养皿的能力或不粘附于塑料培养皿的能力分成2个群体。贴壁细胞和非贴壁细胞都是体外诱导抗绵羊红细胞抗体形成所必需的。贴壁细胞短时间暴露于抗原足以启动最大体外应答。
A suspension of mouse spleen cells can be separated into 2 populations on the basis of their ability or inability to adhere to plastic dishes. Both adherent and nonadherent cells were necessary for the induction of antibody formation to sheep red blood cells in vitro. Exposure of adherent cells to antigen for brief periods of time was sufficient to initiate a maximal in vitro response.