Altered retrobulbar vascular reactivity in early diabetic retinopathy
Altered retrobulbar vascular reactivity in early diabetic retinopathy
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DOI：
10.1136/bjo.81.4.279
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发表时间：
1997-04-01
影响因子：
4.1
通讯作者：
Martin, BJ
中科院分区：
文献类型：
--
作者：
Evans, DW;Harris, A;Martin, BJ
目的/背景——在糖尿病眼病中，导致血液循环受损以及由此导致的视功能丧失的因素知之甚少。尽管视网膜循环已被广泛研究，但它仅占眼部总血流的一小部分。在早期糖尿病性视网膜病变患者的眼睛供血的较大血管中，研究了血液的流动情况。方法：使用眼科和中央视网膜彩色多普勒成像技术，对 11 名患有轻微或无视网膜病变的早期糖尿病患者和 11 名健康对照者的球后血流速度进行了评估 动脉。患者和受试者在呼吸室内空气时进行测试，并在等二氧化碳高氧条件下再次进行测试。结果-高氧引起正常受试者视网膜中央动脉舒张末期速度（EDV）（p = 0.008）和阻力指数（RI）（p = 0.032）的显着变化，但糖尿病患者则不然。因此，在高氧状态下，与正常对照相比，糖尿病患者的 EDV 显着较高（p = 0.006），RI 显着较低（p = 0.002）。高氧对两组的眼动脉均没有造成显着变化。然而，在等二氧化碳高氧条件下，糖尿病患者比正常受试者具有较低的收缩期峰值速度（p = 0.05）和较低的RI（p = 0.05）。结论-与正常受试者相比，施加等二氧化碳高氧会使早期糖尿病患者的眼动脉和视网膜中央动脉血流速度存在显着差异。这些结果表明，视网膜病变极轻微或无视网膜病变的糖尿病患者在为眼睛供血的主要血管中患有不规则的眼部血管功能。
Aim/background-In diabetic eye disease the factors leading to compromised circulation and the resulting loss of visual function are poorly understood. Although retinal circulation has been widely investigated, it accounts for only a fraction of total eye blood how Blood how was investigated in the larger vessels feeding the eye in patients with early diabetic retinopathy.Methods-Eleven patients with early diabetes with minimal or no retinopathy and 11 healthy controls were evaluated for retrobulbar blood flow velocity using colour Doppler imaging for the ophthalmic and central retinal arteries. Patients and subjects were tested while breathing room air and again under conditions of isocapnic hyperoxia.Results-Hyperoxia induced a significant change in the central retinal artery end diastolic velocity (EDV) (p = 0.008) and resistance index (RI) (p = 0.032) in normal subjects, but not in diabetic patients. Consequently, during hyperoxia, the diabetic patients were significantly higher for EDV (p = 0.006) and significantly lower for RI (p = 0.002) compared with normal controls. Hyperoxia caused no significant change in either group in the ophthalmic artery; nevertheless, under isocapnic hyperoxia conditions the diabetic patients had lower peak systolic velocity (p = 0.05) and lower RI (p = 0.05) than normal subjects.Conclusions-Imposition of isocapnic hyperoxia produces significant differences in the ophthalmic and central retinal artery blood flow velocities in diabetic patients with early disease when compared with normal subjects. These results demonstrate that diabetic patients with minimal or no retinopathy suffer from irregular ocular vascular function in the major vessels feeding the eye.