Multiple-type human papillomavirus (HPV) infections: a cross-sectional analysis of the prevalence of specific types in 309,000 women referred for HPV testing at the time of cervical cytology.
Multiple-type human papillomavirus (HPV) infections: a cross-sectional analysis of the prevalence of specific types in 309,000 women referred for HPV testing at the time of cervical cytology.
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DOI：
10.1097/igc.0b013e31829e9fb4
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发表时间：
2013-09
期刊：
影响因子：
--
通讯作者：
Downs LS Jr
中科院分区：
文献类型：
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作者：
Dickson EL;Vogel RI;Bliss RL;Downs LS Jr
确定多型宫颈HPV感染的频率，以及如果这些感染随机发生，是否有任何类型涉及多型感染的频率高于或低于预期。在这项对特定类型HPV检测的回顾性分析中，研究人员考虑了2007年7月至2011年5月期间收集的18-65岁女性样本的结果。使用多变量logistic回归分析对24种最流行的HPV类型中的每一种的存在进行建模，调整另一种HPV类型、年龄、实验室区域和区域相互作用的年龄。309,471名妇女中有74,543人（24.1%）感染HPV， 65,492人（21.1%）对前24种最流行的HPV类型之一呈阳性。最常见的HPV类型是HPV 16型，占整个样本的4.1%。14181名女性2种或2种以上HPV类型呈阳性（占全部样本的4.6%，占HPV阳性样本的19.0%）。分析双向HPV型别比较。52型、53型、81型和83型在与其他类型的多重感染中更容易发生，16型、58型和66型在与其他类型的多重感染中发生的可能性较小。HPV 72型和81型的正相关最强（OR=5.2, 95% CI: 3.6, 7.4）。HPV 33型和66型的相关性最强（OR 0.4, 95% CI: 0.2, 0.6）。在这一人群中，4.6%的女性存在多型HPV感染。我们的研究结果表明，HPV类型之间可能存在竞争和合作的相互作用。
To determine the frequency of multiple type cervical HPV infections, and whether any types are involved in multiple type infections more or less frequently than might be expected if these infections occur randomly. In this retrospective analysis of type-specific HPV testing, results from women 18-65 years old with samples collected between July 2007 and May 2011 were considered. Multivariate logistic regression analysis was used to model the presence of each of the 24 most prevalent HPV types, adjusting for one other HPV type, age, laboratory region, and age by region interactions. HPV infection was present in 74,543 of 309,471 women (24.1%) and 65,492 (21.1%) were positive for one of the top 24 most prevalent HPV types. The most common HPV type was HPV type 16, occurring in 4.1 of the entire sample%. 14,181 women were positive for 2 or more HPV types (4.6% of entire sample, 19.0% of HPV positive sample). Two-way HPV type comparisons were analyzed. Types 52, 53, 81, and 83 more likely to occur in multiple infections with other types, and types 16, 58, and 66 were less likely to occur in multiple infections with other types. HPV types 72 and 81 have the strongest positive relationship (OR=5.2, 95% CI: 3.6, 7.4). HPV types 33 and 66 have the strongest negative relationship (OR 0.4, 95% CI: 0.2, 0.6). In this population, multiple type HPV infections were present in 4.6% of all women. Our findings suggest that there may be both competitive and cooperative interactions between HPV types.