Adult systemic anaplastic large-cell lymphoma: recommendations for diagnosis and management.
Adult systemic anaplastic large-cell lymphoma: recommendations for diagnosis and management.
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DOI：
10.1586/17474086.2016.1122514
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发表时间：
2016
影响因子：
2.8
通讯作者：
Feldman AL
中科院分区：
文献类型：
--
作者：
Bennani-Baiti N;Ansell S;Feldman AL
Systemic anaplastic large cell lymphomas (sALCLs) comprise a heterogeneous group of relatively rare T-cell non-Hodgkin lymphomas characterized by CD30 expression and other unifying pathologic features. ALK fusions are present in about 50% of cases. Pathological diagnosis can be challenging, particularly in ALK-negative cases. Though ALK-positive and ALK-negative sALCL are similar morphologically and immunophenotypically, they are separate entities with different genetics, clinical behavior, and outcomes. Evidence-based data evaluating treatment regimens are limited as randomized controlled trials are lacking and most prospective studies are too small to draw definitive conclusions. However, recent advances in molecular biology are bringing forth much needed knowledge in this field, and are likely to guide further targeted therapeutic development.
