Hippocampal and parahippocampal volumes vary by sex and traumatic life events in children
Hippocampal and parahippocampal volumes vary by sex and traumatic life events in children
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DOI：
10.1503/jpn.190013
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发表时间：
2020-07-01
影响因子：
4.3
通讯作者：
Wilson, Tony W.
中科院分区：
文献类型：
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作者：
Badura-Brack, Amy S.;Mills, Mackenzie S.;Wilson, Tony W.
儿童期创伤与成年人海马体积较小有可靠的相关性;然而，这一发现尚未在儿童中得到证实，关于性别和创伤如何相互作用影响儿童边缘系统结构发育的研究更是少之又少（n = 172; 85名女性，87名男性）。所有报告4次或更多创伤的儿童（n = 36）组成高创伤组，所有报告3次或更少创伤的儿童（n = 136）组成低创伤组。使用多变量协方差分析，我们比较了FreeSurfer衍生的结构MRI体积（归一化总颅内体积）的杏仁核，海马和海马旁区的性别和创伤水平，控制年龄和studysite.ResultsWe发现一个显着的性别x创伤的相互作用，这样的女孩与高创伤有更大的体积比男孩与高创伤。随访分析表明，女孩的体积显着增加，男孩的体积普遍减少，特别是在海马和海马旁区域的高创伤组;我们观察到在低创伤组没有性别差异。我们注意到没有交互作用的amygdalae.LimitationsWe评估了社区样本，并没有包括临床样本。我们没有收集数据的年龄在儿童经历traumatic.ConclusionResults显示，心理创伤影响大脑发育不同的女孩和男孩。这些发现需要纵向跟进，以阐明结构差异的进展，并有助于众所周知的性别差异的精神病理学。
BackgroundChildhood trauma is reliably associated with smaller hippocampal volume in adults; however, this finding has not been shown in children, and even less is known about how sex and trauma interact to affect limbic structural development in children.MethodsTypically developing children aged 9 to 15 years who completed a trauma history questionnaire and structural T-1-weighted MRI were included in this study (n = 172; 85 female, 87 male). All children who reported 4 or more traumas (n = 36) composed the high trauma group, and all children who reported 3 or fewer traumas (n = 136) composed the low trauma group. Using multivariate analysis of covariance, we compared FreeSurfer-derived structural MRI volumes (normalized by total intracranial volume) of the amygdalar, hippocampal and parahippocampal regions by sex and trauma level, controlling for age and study site.ResultsWe found a significant sex x trauma interaction, such that girls with high trauma had greater volumes than boys with high trauma. Follow-up analyses indicated significantly increased volumes for girls and generally decreased volumes for boys, specifically in the hippocampal and parahippocampal regions for the high trauma group; we observed no sex differences in the low trauma group. We noted no interaction effect for the amygdalae.LimitationsWe assessed a community sample and did not include a clinical sample. We did not collect data about the ages at which children experienced trauma.ConclusionResults revealed that psychological trauma affects brain development differently in girls and boys. These findings need to be followed longitudinally to elucidate how structural differences progress and contribute to well-known sex disparities in psychopathology.