T lymphocytes: ontogeny, function, and relevance to clinical disorders.
T lymphocytes: ontogeny, function, and relevance to clinical disorders.
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T 淋巴细胞：个体发育、功能以及与临床疾病的相关性。
DOI：
10.1056/nejm198710293171807
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Reinherz,EL
中科院分区：
文献类型：
--
作者：
Royer,HD;Reinherz,EL
与B淋巴细胞不同，t淋巴细胞主要识别与主要组织相容性复合体（MHC）的膜结合产物相关的抗原。这种“双重”识别（即对抗原和MHC的双重识别）对于细胞毒性效应T细胞和免疫调节性T细胞的激活都很重要。细胞毒性T细胞裂解特异性靶细胞，包括肿瘤细胞和感染病毒的细胞，而免疫调节性T细胞作为诱导或抑制T细胞、B细胞、巨噬细胞和其他细胞之间的相互作用。长期以来，人们一直认为T细胞的特异性是由独特的、克隆分布的（克隆型）细胞表面受体决定的。因为……
T-lymphocytes, unlike B lymphocytes, predominantly recognize antigen when it is associated with membrane-bound products of the major histocompatibility complex (MHC).123This "dual" recognition (i.e., for both antigen and the MHC) is important for activation of both cytotoxic effector T cells and immunoregulatory T cells. Cytotoxic T cells lyse specific target cells, including tumor cells and cells infected with virus, whereas immunoregulatory T cells act as inducers or suppressors for interactions among T cells, B cells, macrophages, and other cells.The exquisite specificity of T cells has long been thought to be determined by unique, clonally distributed (clonotypic) cell-surface receptors. Because . . .