Gadolinium-free assessment of synovitis using diffusion tensor imaging.
Gadolinium-free assessment of synovitis using diffusion tensor imaging.
复制标题
DOI：
10.1002/nbm.4614
复制
发表时间：
2022-01
影响因子：
2.9
通讯作者：
Mazzoli V
中科院分区：
文献类型：
--
作者：
Sandford HJC;MacKay JW;Watkins LE;Gold GE;Kogan F;Mazzoli V
动态对比增强 (DCE)-MRI 参数 Ktrans 可以量化患有骨关节炎 (OA) 的膝盖滑膜炎症 (滑膜炎) 的强度，但需要使用钆基造影剂 (GBCA)。扩散张量成像 (DTI) 通过参数平均扩散率 (MD) 和分数各向异性 (FA) 测量水分子的扩散，并已被提议作为一种不使用 GBCA 来检测滑膜炎症的方法。本研究的目的是 (1) 通过将 MD 和 FA 与滑膜内成像金标准 Ktrans 进行比较，确定 DTI 量化 OA 滑膜炎强度的能力；(2) 将 DTI 和 DCE-MRI 测量值与 Kellgren-Lawrence (KL) 和 MRI 骨关节炎膝关节评分 (MOAKS) 系统的 OA 严重程度半定量分级进行比较，以评估滑膜炎强度之间的关系和 OA 严重程度。在滑膜内，MD 与 Ktrans 呈显着正相关（r = 0.79，p < 0.001），而 FA 与 Ktrans 呈显着负相关（r = -0.72，p = 0.0026）。这些结果表明，DTI 能够在不使用外源性造影剂的情况下量化整个滑膜内滑膜炎的强度。此外，当膝盖按 KL 等级分开时，MD、FA 和 Ktrans 值没有显着变化（分别为 p = 0.15、p = 0.32、p = 0.41），而 MD（r = 0.60，p = 0.018）和 Ktrans（r = 0.62，p = 0.013）具有显着正相关性，FA（r = -0.53，p = 0.043）与 MOAKS 呈负相关。这些比较表明，除了形态学评估之外，滑膜炎强度的定量测量还可以提供评估 OA 严重程度的信息。使用 DTI 在没有 GBCA 的情况下量化滑膜炎的强度可能有助于促进对 OA 严重程度进行更广泛的临床评估。
The dynamic contrast-enhanced (DCE)-MRI parameter Ktrans can quantify the intensity of synovial inflammation (synovitis) in knees with osteoarthritis (OA), but requires the use of gadolinium-based contrast agent (GBCA). Diffusion tensor imaging (DTI) measures the diffusion of water molecules with parameters mean diffusivity (MD) and fractional anisotropy (FA), and has been proposed as a method to detect synovial inflammation without the use of GBCA. The purpose of this study is to (1) determine the ability of DTI to quantify the intensity of synovitis in OA by comparing MD and FA with our imaging gold standard Ktrans within the synovium and (2) compare DTI and DCE-MRI measures with the semi-quantitative grading of OA severity with the Kellgren-Lawrence (KL) and MRI Osteoarthritis Knee Score (MOAKS) systems, in order to assess the relationship between synovitis intensity and OA severity. Within the synovium, MD showed a significant positive correlation with Ktrans (r = 0.79, p < 0.001), while FA showed a significant negative correlation with Ktrans (r = −0.72, p = 0.0026). These results show that DTI is able to quantify the intensity of synovitis within the whole synovium without the use of exogenous contrast agent. Additionally, MD, FA, and Ktrans values did not vary significantly when knees were separated by KL grade (p = 0.15, p = 0.32, p = 0.41, respectively), while MD (r = 0.60, p = 0.018) and Ktrans (r = 0.62, p = 0.013) had a significant positive correlation and FA (r = −0.53, p = 0.043) had a negative correlation with MOAKS. These comparisons indicate that quantitative measures of the intensity of synovitis may provide information in addition to morphological assessment to evaluate OA severity. Using DTI to quantify the intensity of synovitis without GBCA may be helpful to facilitate a broader clinical assessment of the severity of OA.
登录
查看更多内容
DOI：
10.1016/s0140-6736(18)32203-7
发表时间：
2018-11-10
期刊：
Lancet (London, England)
影响因子：
--
作者：
GBD 2017 Causes of Death Collaborators
通讯作者：
GBD 2017 Causes of Death Collaborators
影响因子：
3.5
作者：
Garyfallidis E;Brett M;Amirbekian B;Rokem A;van der Walt S;Descoteaux M;Nimmo-Smith I;Dipy Contributors
通讯作者：
Dipy Contributors
影响因子：
3.3
作者：
Fair, Merlin J.;Liao, Congyu;Setsompop, Kawin
通讯作者：
Setsompop, Kawin
影响因子：
3.3
作者：
Reeder, SB;Wintersperger, BJ;Schoenberg, SO
通讯作者：
Schoenberg, SO
影响因子：
2.8
作者：
Krenn, V;Morawietz, L;König, A
通讯作者：
König, A