A mitochondria-targeted nanoradiosensitizer activating reactive oxygen species burst for enhanced radiation therapy.
A mitochondria-targeted nanoradiosensitizer activating reactive oxygen species burst for enhanced radiation therapy.
复制标题
一种靶向线粒体的纳米放射增敏剂激活活性氧爆发以增强放射治疗
DOI：
10.1039/c7sc04458e
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发表时间：
2018-03-28
期刊：
影响因子：
8.4
通讯作者：
Tang B
中科院分区：
文献类型：
--
作者：
Li N;Yu L;Wang J;Gao X;Chen Y;Pan W;Tang B
我们开发了一种基于线粒体靶向二氧化钛-金纳米放射增敏剂的增强放射治疗的新策略。放射治疗已广泛应用于恶性肿瘤的治疗。然而，临床肿瘤治疗中的大剂量电离辐射和高频率放射治疗对肿瘤邻近的正常组织造成了严重的损伤。因此，如何提高局部治疗效果，减少对正常组织的损伤一直是RT的挑战。在此，我们开发了一种新的策略，用于增强RT的基础上线粒体靶向二氧化钛-金纳米放射增敏剂。当X射线照射时，纳米增敏剂可以在线粒体中产生活性氧，从而引起活性氧爆发的多米诺效应。过量产生的活性氧在线粒体中积累，导致线粒体崩溃和不可逆的细胞凋亡。集落形成测定表明，当与线粒体靶向纳米敏化剂孵育时，细胞存活率显著低于非靶向组。如通过体内实验所证明的，即使用纳米增敏剂进行一次RT，肿瘤也被显著抑制。
We developed a novel strategy for enhanced radiation therapy based on a mitochondria targeted titanium dioxide-gold nanoradiosensitizer. Radiation therapy (RT) has been widely used for malignant tumor treatment. However, the large dosage of ionizing radiation and high frequency of radiotherapy in clinical cancer therapy cause severe damage to normal tissues adjacent to tumors. Therefore, how to increase the local treatment efficacy and reduce the damage to normal tissues has been a challenge for RT. Herein, we developed a novel strategy for enhanced RT based on a mitochondria targeted titanium dioxide-gold nanoradiosensitizer. When irradiated with X-rays, the nanosensitizer could produce reactive oxygen species (ROS) in the mitochondria, which induced the domino effect on the ROS burst. The overproduced ROS accumulated in mitochondria, resulting in mitochondrial collapse and irreversible cell apoptosis. A colony formation assay indicated that the cell survival rate when incubated with the mitochondrial targeted nanosensitizer was significantly lower than that of non-targeted groups. As demonstrated by in vivo experiments, the tumor was significantly suppressed even just once RT with the nanosensitizer.
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DOI：
10.1016/j.biocel.2009.02.016
发表时间：
2009-10
影响因子：
4
作者：
Aon, M. A.;Cortassa, S.;Akar, F. G.;Brown, D. A.;Zhou, L.;O'Rourke, B.
通讯作者：
O'Rourke, B.
影响因子：
6.2
作者：
Delaney, G;Jacob, S;Barton, M
通讯作者：
Barton, M
影响因子：
--
作者：
Rico-Bautista E;Zhu W;Kitada S;Ganapathy S;Lau E;Krajewski S;Ramirez J;Bush JA;Yuan Z;Wolf DA
通讯作者：
Wolf DA
影响因子：
3.1
作者：
Hatz, Sonja;Lambert, John D. C.;Ogilby, Peter R.
通讯作者：
Ogilby, Peter R.
DOI：
10.1073/pnas.0307156101
发表时间：
2004-03-30
影响因子：
11.1
作者：
Aon, MA;Cortassa, S;O'Rourke, B
通讯作者：
O'Rourke, B