Natural history of nonstenotic, asymptomatic ulcerative lesions of the carotid artery.
Natural history of nonstenotic, asymptomatic ulcerative lesions of the carotid artery.
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颈动脉非狭窄、无症状溃疡性病变的自然史。
DOI：
10.1001/archsurg.1978.01370230142018
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发表时间：
1978
影响因子：
--
通讯作者：
R. Mani
中科院分区：
文献类型：
--
作者：
W. Moore;C. Boren;J. Malone;A. J. Roon;R. Eisenberg;J. Goldstone;R. Mani
为了明确无症状、非狭窄、溃疡性病变累及颈动脉分叉的自然史，我们回顾了67例患者的72处无症状溃疡性病变的动脉造影和临床病程。溃疡的血管造影表现分为三组：轻微（A组）、大（B组）和复合（C组）。使用寿命表的方法，这些患者的临床过程进行了比较组之间，也进行了比较，一个非随机手术治疗组的非狭窄性溃疡性病变的患者进行手术半球或单眼症状。死亡率无显著差异（P>.1），但卒中发生率差异非常显著（P <.001）。7年平均的年卒中率，A组为0.4%/年，手术治疗组为1.47%/年，B和C组为12.5%/年。数据表明，A组溃疡具有良性预后，与B和C组溃疡形成明显对比，B和C组溃疡引起后续卒中的高风险。
To define the natural history of the asymptomatic, nonstenotic, ulcerative lesion involving the carotid artery bifurcation, the arteriograms and clinical course of 67 patients with 72 asymptomatic ulcerative lesions of the carotid artery were reviewed. The angiographic appearance of ulceration was classified into three groups: minimal (group A), large (group B), and compound (group C). Using life-table methods, the clinical course of these patients was compared between groups and was also compared to a nonrandomized surgically treated group of patients with nonstenotic ulcerative lesions in whom operation was performed for hemispheric or monocular symptoms. There were no significant (P greater than .1) differences in mortality, but the differences in stroke incidence was highly significant (P less than .001). The annual stroke rate, averaged over seven years, was 0.4% per year for group A, 1.47% per year for the surgically treated group, and 12.5% per year for groups B and C. The data indicate that group A ulcers have a benign prognosis, in noticeable contrast to group B and C ulcers which incur a high risk for subsequent stroke.