Teaching resources. Spatial and temporal dynamics of signaling components involved in the control of chemotaxis in Dictyostelium discoideum.
Teaching resources. Spatial and temporal dynamics of signaling components involved in the control of chemotaxis in Dictyostelium discoideum.
复制标题
教学资源。
DOI：
10.1126/stke.2342004tr3
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Gough,NancyR
中科院分区：
文献类型：
--
作者：
Kimmel,AlanR;Parent,CaroleA;Gough,NancyR
这个动画显示了在单细胞生物盘状网柄藻对化学引诱物cAMP的趋化反应过程中几种蛋白质的重新分布。就像中性粒细胞一样，这种生物体能够感知并向非常浅的趋化剂梯度移动。在编码各种信号传导组分的基因中携带突变的突变菌株是可用的，因此，D. discoideum作为一种模式生物的细胞机制，控制趋化性和放大信号梯度在一个单一的细胞研究。动画将有助于描绘信号转导的动态性质，细胞的能力，以允许定向运动，并在空间和时间的变化，伴随着趋化反应的特定蛋白质的活性。
This animation shows the redistribution of several proteins during the chemotactic response of the single-celled organismDictyostelium discoideumto the chemoattractant cAMP. Much like neutrophils, this organism is able to sense and move toward very shallow gradients of chemoattractant. Mutant strains carrying mutations in genes encoding various signaling components are available and, thus,D. discoideumserves as a model organism for the study of the cellular mechanisms that control chemotaxis and amplification of a signaling gradient across a single cell. The animation would be useful in depicting the dynamic nature of signal transduction, the ability of cells to polarize to allow for directional movement, and the spatial and temporal changes in the activity of specific proteins that accompany chemotactic responses.